Zebrafish models for attention deficit hyperactivity disorder (ADHD)

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:100

Review

Fontana, Barbara D.¹  Franscescon, Francini²  Rosemberg, Denis B.^2,11  Norton, William H. J.^3,11  Kalueff, Allan V.^{4,5,6,7,8,9,10,11}  Parker, Matthew O.^1,11 

[1] Univ Portsmouth, Sch Pharm & Biomed Sci, Brain & Behav Lab, Portsmouth, Hants, England

[2] Univ Fed Santa Maria, Grad Program Biol Sci, Toxicol Biochem, 1000 Roraima Ave, BR-97105900 Santa Maria, RS, Brazil

[3] Univ Leicester, Dept Neurosci Psychol & Behav, Coll Med Biol Sci & Psychol, Leicester LE1 7RH, Leics, England

[4] Southwest Univ, Sch Pharm, Chongqing 400700, Peoples R China

[5] Minist Healthcare Russian Federat, Inst Translat Biomed, Almazov Natl Med Res Ctr, St Petersburg 199034, Russia

[6] ZENEREI Res Ctr, Neuropharmacol Lab, Slidell, LA 70458 USA

[7] St Petersburg State Univ, Lab Biol Psychiat, ITBM, St Petersburg 199034, Russia

[8] Sci Res Inst Physiol & Basic Med, Novosibirsk 630117, Russia

[9] Minist Healthcare Russian Federat, Granov Russian Sci Ctr Radiol & Surg Technol, St Petersburg 197758, Russia

[10] Ural Fed Univ, Ekaterinburg 620002, Russia

[11] Int Zebrafish Neurosci Res Consortium ZNRC, 309 Palmer Court, Slidell, LA 70458 USA

关键词: ADHD;    Zebrafish;    Behavior;    Genetics;    Dopamine;    Noradrenaline;    Serotonin;   

DOI  :  10.1016/j.neubiorev.2019.02.009

来源: Elsevier

【 摘 要 】

Attention deficit hyperactivity disorder (ADHD) is a common, debilitating neurodevelopmental disorder associated with inattentiveness, pathological hyperactivity and impulsivity. Despite the mounting human and animal evidence, the neurological pathways underlying ADHD remain poorly understood. Novel translational model organisms, such as the zebrafish (Dario rerio), are becoming important tools to investigate genetic and pathophysiological mechanisms of various neuropsychiatric disorders. Here, we discuss ADHD etiology, existing animal models and their limitations, and emphasize the advantages of using zebrafish to model ADHD. Overall, the growing utility of zebrafish models may improve our understanding of ADHD and facilitate drug discovery to prevent or treat this disorder.

【 授权许可】

Free