Obsessive-compulsive disorder: Insights from animal models

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:76

Review

Szechtman, Henry¹  Ahmari, Susanne E.²  Beninger, Richard J.^3,4  Eilam, David⁵  Harvey, Brian H.⁶  Edemann-Callesen, Henriette⁷  Winter, Christine⁷ 

[1] McMaster Univ, Dept Psychiat & Behav Neurosci, Hamilton, ON, Canada

[2] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA USA

[3] Queens Univ, Dept Psychol, 62 Arch St, Kingston, ON K7L 3N6, Canada

[4] Queens Univ, Dept Psychiat, Kingston, ON, Canada

[5] Tel Aviv Univ, Dept Zool, IL-69978 Ramat Aviv, Israel

[6] North West Univ, Sch Pharm, Ctr Excellence Pharmaceut Sci, MRC Unit Anxiety & Stress Disorders, Potchefstroom, South Africa

[7] Tech Univ Dresden, Univ Klinikum Carl Gustav Carus, Klin & Poliklin Psychiat & Psychotherapie, Bereich Expt Psychiat, Dresden, Germany

关键词: Quinpirole;    Security motivation system;    Animal model;    Nucleus accumbens core;    Obsessive-compulsive disorder;    Orbitofrontal cortex;    Striatum;    Basal ganglia;    Deer mouse;    Endophenotypes;   

DOI  :  10.1016/j.neubiorev.2016.04.019

来源: Elsevier

【 摘 要 】

Research with animal models of obsessive-compulsive disorder (OCD) shows the following: (1) Optogenetic studies in mice provide evidence for a plausible cause-effect relation between increased activity in cortico-basal ganglia-thalamo-cortical (CBGTC) circuits and OCD by demonstrating the induction of compulsive behavior with the experimental manipulation of the CBGTC circuit. (2) Parallel use of several animal models is a fruitful paradigm to examine the mechanisms of treatment effects of deep brain stimulation in distinct OCD endophenotypes. (3) Features of spontaneous behavior in deer mice constitute a rich platform to investigate the neurobiology of OCD, social ramifications of a compulsive phenotype, and test novel drugs. (4) Studies in animal models for psychiatric disorders comorbid with OCD suggest comorbidity may involve shared neural circuits controlling expression of compulsive behavior. (5) Analysis of compulsive behavior into its constitutive components provides evidence from an animal model for a motivational perspective on OCD. (6) Methods of behavioral analysis in an animal model translate to dissection of compulsive rituals in OCD patients, leading to diagnostic tests. (C) 2016 Elsevier Ltd. All rights reserved.

【 授权许可】

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