Expression of Sfrp5/Wnt5a in human epicardial adipose tissue and their relationship with coronary artery disease

LIFE SCIENCES

卷:245

Article

Tong, Shan^1,2  Du, Yu¹  Ji, Qingwei³  Dong, Ran⁴  Cao, Jian⁴  Wang, Zhijian¹  Li, Wei²  Zeng, Min²  Chen, Hongying⁵  Zhu, Xiaogang¹  Zhou, Yujie¹ 

[1] Capital Med Univ, Beijing Anzhen Hosp, Dept Cardiol,Clin Ctr Coronary Heart Dis, Beijing Inst Heart Lung & Blood Vessel Dis,Beijin, Beijing 100029, Peoples R China

[2] Hainan Gen Hosp, Ctr Geriatr, Haikou 580000, Hainan, Peoples R China

[3] Capital Med Univ, Beijing Anzhen Hosp, Emergency & Crit Care Ctr, Beijing 100029, Peoples R China

[4] Capital Med Univ, Beijing Anzhen Hosp, Dept Cardiac Surg Ctr, Ward 11, Beijing 100029, Peoples R China

[5] Jackson Clin, Phys Therapy, Middleburg, VA 20117 USA

关键词: Epicardial adipose tissue;    Sfrp5;    Wnt5a;    Atherosclerosis;    Coronary artery disease;   

DOI  :  10.1016/j.lfs.2020.117338

来源: Elsevier

【 摘 要 】

Secreted frizzled-related protein 5 (Sfrp5) primarily acts in combination with wingless-type family member 5a (Wnt5a), to inhibits chronic inflammation and repress atherosclerosis and other metabolic disorders. Epicardial adipose tissue (EAT), surrounding the heart and coronary arteries, has been found to be highly related to the progression of coronary artery disease through adipokines production. However, little is known about EAT-derived Sfrp5 and Wnt5a in humans. We aimed to investigate whether the EAT-derived Sfrp5/Wnt5a levels are altered in patients with CAD. Fifty-eight patients with CAD and 29 patients without CAD who underwent cardiac surgery were enrolled. Serum samples and paired adipose biopsies from EAT and subcutaneous adipose tissue (SAT) were collected, and Sfrp5 and Wnt5a levels were detected. Correlation and multivariate regression analyses were performed to determine the relationship between Sfrp5/Wnt5a expression and CAD and other clinical risk factors. According to the results, the CAD group had lower Sfrp5 and higher Wnt5a levels in EAT and serum (all p < 0.05). Serum Sfrp5 levels were significantly lower in CAD patients with impaired myocardial function. EAT Sfrp5 mRNA levels and serum Sfrp5 levels were both negatively associated with the presence of CAD, after adjustment for known biomarkers, EAT mRNA and serum Wnt5a levels correlated positively with the presence of CAD. Thus, we concluded that low Sfrp5 and high Wnt5a levels are associated with the presence of CAD, independent of other conventional risk factors.

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