Epigenetic control of atherosclerosis via DNA methylation: A new therapeutic target?

LIFE SCIENCES

卷:253

Review

Gorabi, Armita Mahdavi¹  Penson, Peter E.²  Banach, Maciej^3,4  Motallebnezhad, Morteza^5,6,7  Jamialahmadi, Tannaz⁹  Sahebkar, Amirhossein^8,10,11 

[1] Univ Tehran Med Sci, Res Ctr Adv Technol Cardiovasc Med, Tehran Heart Ctr, Tehran, Iran

[2] Liverpool John Moores Univ, Sch Pharm & Biomol Sci, Liverpool, Merseyside, England

[3] Med Univ Lodz, WAM Univ Hosp Lodz, Dept Hypertens, Zeromskiego 113, Lodz, Poland

[4] PMMHRI, Lodz, Poland

[5] Tabriz Univ Med Sci, Immunol Res Ctr, Tabriz, Iran

[6] Tabriz Univ Med Sci, Student Res Comm, Tabriz, Iran

[7] Iran Univ Med Sci, Dept Immunol, Fac Med, Tehran, Iran

[8] FDA, Halal Res Ctr IRI, Tehran, Iran

[9] Mashhad Univ Med Sci, Dept Nutr, Fac Med, Mashhad, Razavi Khorasan, Iran

[10] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Razavi Khorasan, Iran

[11] Mashhad Univ Med Sci, Neurogen Inflammat Res Ctr, Mashhad, Razavi Khorasan, Iran

关键词: Atherosclerosis;    Epigenetic regulation;    DNA methylation;    Oxidative stress;    Inflammation;   

DOI  :  10.1016/j.lfs.2020.117682

来源: Elsevier

【 摘 要 】

Atherosclerosis is a disease in which lipid-laden plaques are developed inside the vessel walls of arteries. The immune system is activated, resulting in inflammation and oxidative stress. Endothelial cells (ECs) are activated, arterial smooth muscle cells (SMCs) proliferate, macrophages are activated, and foam cells are developed, leading to dysfunctional ECs. Epigenetic regulatory mechanisms, including DNA methylation, histone modifications, and microRNAs are involved in the modulation of genes that play distinct roles in several aspects of cell biology and physiology, hence linking environmental stimuli to gene regulation. Recent research has investigated the involvement of DNA methylation in the etiopathogenesis of atherosclerosis, and several studies have documented the role of this mechanism in various aspects of the disease. Regulation of DNA methylation plays a critical role in the integrity of ECs, SMC proliferation and formation of atherosclerotic lesions. In this review, we seek to clarify the role of DNA methylation in the development of atherosclerosis through different mechanisms.

【 授权许可】

Free