Modelling human prostate cancer: Rat models

LIFE SCIENCES

卷:203

Review

Nascimento-Goncalves, Elisabete¹  Faustino-Rocha, Ana I.^2,3  Seixas, Fernanda^1,4  Ginja, Mario^1,2  Colaco, Bruno^2,5  Ferreira, Rita⁶  Fardilha, Margarida⁷  Oliveira, Paula A.^1,2 

[1] Univ Tras Os Montes & Alto Douro UTAD, Dept Vet Sci, Vila Real, Portugal

[2] UTAD, Ctr Res & Technol Agroenvironm & Biol Sci CITAB, Vila Real, Portugal

[3] Lusophone Univ Human & Technol, Fac Vet Med, Lisbon, Portugal

[4] UTAD, Anim & Vet Res Ctr CECAV, Vila Real, Portugal

[5] Univ Tras Os Montes & Alto Douro UTAD, Dept Zootech, Vila Real, Portugal

[6] Univ Aveiro, Mass Spectrometry Ctr, Organ Chem Nat Prod & Foodstuffs QOPNA, Aveiro, Portugal

[7] UA, Med Sci Dept, Inst Res Biomed, Lab Signal Transduct, Aveiro, Portugal

关键词: Animal models;    Image monitoring;    Prostate carcinogenesis;    Rats;   

DOI  :  10.1016/j.lfs.2018.04.014

来源: Elsevier

【 摘 要 】

Prostate cancer is the second most common cancer in men, affecting approximately 1.1 million men worldwide. In this way, the study of prostate cancer biopathology and the study of new potential therapies is of paramount importance. Several rat models were developed over the years to study prostate cancer, namely spontaneous models, chemically-induced models, implantation of cancer cell lines and genetically-engineered models. This manuscript aimed to provide the readers with an overview of the rat models of prostate cancer, highlighting their advantages and disadvantages, as well as, their applications.

【 授权许可】

Free