Castelli risk indexes 1 and 2 are higher in major depression but other characteristics of the metabolic syndrome are not specific to mood disorders

LIFE SCIENCES

卷:102

Article

Vargas, Heber Odebrecht^1,2  Vargas Nunes, Sandra Odebrecht^1,2  Barbosa, Decio Sabbatini³  Vargas, Mateus Mendonca²  Cestari, Ariane²  Dodd, Seetal^4,5,7  Venugopal, Kamalesh^4,7  Maes, Michael^1,5,7,8  Berk, Michael^4,5,6,7,9 

[1] Univ Estadual Londrina, Univ Hosp, Hlth Sci Ctr, Dept Psychiat, BR-86035380 Londrina, Parana, Brazil

[2] Univ Estadual Londrina, Univ Hosp, Ctr Approach & Treatment Smokers, BR-86051990 Londrina, Parana, Brazil

[3] Univ Estadual Londrina, Hlth Sci Ctr, Dept Clin Anal & Toxicol, Londrina, Parana, Brazil

[4] Univ Melbourne, Dept Psychiat, Parkville, Vic 3052, Australia

[5] Deakin Univ, Sch Med, Geelong, Vic 3217, Australia

[6] Univ Melbourne, Ctr Youth Mental Hlth, Orygen Youth Hlth Res Ctr, Parkville, Vic 3052, Australia

[7] Swanston Ctr, Barwon Hlth & Geelong Clin, Geelong, Vic 3220, Australia

[8] Chulalongkorn Univ, Dept Psychiat, Bangkok, Thailand

[9] Florey Inst Neurosci & Mental Hlth, Parkville, Vic, Australia

关键词: Metabolic syndrome;    Bipolar disorder;    Depression;    Cholesterol;    HDL;    Inflammation;    Oxidative stress;    Antioxidants;   

DOI  :  10.1016/j.lfs.2014.02.033

来源: Elsevier

【 摘 要 】

Aims: This study examined whether Castelli risk indexes 1 (total/high-density lipoprotein (HDL) cholesterol) and 2 (low density lipoprotein (LDL)/HDL cholesterol) and other shared metabolic disorders might underpin the pathophysiology of the metabolic syndrome, major depression or bipolar disorder. Main methods: This cross-sectional study examined 92 major depressed, 49 bipolar depressed and 201 normal controls in whom the Castelli risk indexes 1 and 2 and key characteristics of the metabolic syndrome, i.e. waist/hip circumference, body mass index (BMI), systolic/diastolic blood pressure, total cholesterol, low-density lipoprotein (LDL) and HDL cholesterol, triglycerides, insulin, glucose, hemoglobin Alc (HbA1c) and homocysteine were assessed. Key findings: Castelli risk indexes 1 and 2 were significantly higher in major depressed patients than in bipolar disorder patients and controls. There were no significant differences in waist or hip circumference, total and LDL cholesterol, triglycerides, plasma glucose, insulin, homocysteine and HbAl c between depression and bipolar patients and controls. Bipolar patients had a significantly higher BMI than major depressed patients and normal controls. Significance: Major depression is accompanied by increased Castelli risk indexes 1 and 2, which may be risk factors for cardiovascular disease. Other key characteristics of the metabolic syndrome, either metabolic biomarkers or central obesity, are not necessarily specific to major depression or bipolar disorder. (c) 2014 Elsevier Inc All rights reserved.

【 授权许可】

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