Metabolic syndrome among psychiatric outpatients with mood and anxiety disorders

BMC Psychiatry

Research Article

Nan-Wen Yu¹  Chun-Lin Chu¹  Chia-Yih Liu²  Ching-I Hung²  Mei-Chun Hsiao² 

[1] Department of Psychiatry, Chang-Gung Memorial Hospital at Linkou, 5 Fu-Shing St, Kweishan, 333, Taoyuan, Taiwan;Department of Psychiatry, Chang-Gung Memorial Hospital at Linkou, 5 Fu-Shing St, Kweishan, 333, Taoyuan, Taiwan;Chang-Gung University School of Medicine, Taoyuan, Taiwan;

关键词: Bipolar disorder;    Depression;    Anxiety;    Metabolic syndrome;   

DOI  :  10.1186/1471-244X-14-185

 received in 2013-07-01, accepted in 2014-06-17,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundFew studies have simultaneously compared the impacts of pharmacotherapy and mental diagnoses on metabolic syndrome (MetS) among psychiatric outpatients with mood and anxiety disorders. This study aimed to investigate the impacts of pharmacotherapy and mental diagnoses on MetS and the prevalence of MetS among these patients.MethodsTwo-hundred and twenty-nine outpatients (men/women = 85/144) were enrolled from 1147 outpatients with mood and anxiety disorders by systematic sampling. Psychiatric disorders and MetS were diagnosed using the Structured Clinical Interview for DSM-IV-TR and the new International Diabetics Federation definition, respectively. The numbers of antipsychotics, mood stabilizers, and antidepressants being taken were recorded. Logistic regression was used to investigate the impacts of pharmacotherapy and psychiatric diagnoses on MetS.ResultsAmong 229 subjects, 51 (22.3%) fulfilled the criteria for MetS. The prevalence of MetS was highest in the bipolar I disorder (46.7%) patients, followed by bipolar II disorder (25.0%), major depressive disorder (22.0%), anxiety-only disorders (16.7%), and no mood and/or anxiety disorders (14.3%). The percentages of MetS among the five categories were correlated with those of the patients being treated with antipsychotics and mood stabilizers. Use of antipsychotics and/or mood stabilizers independently predicted a higher risk of MetS after controlling for demographic variables and psychiatric diagnoses. When adding body mass index (BMI) as an independent variable in the regression model, BMI became the most significant factor to predict MetS.ConclusionBMI was found to be an important factor related to MetS. Pharmacotherapy might be one of underlying causes of elevated BMI. The interactions among MetS, BMI, pharmacotherapy, and psychiatric diagnoses might need further research.

【 授权许可】

Unknown   
© Hung et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.