Self-organizing magnetic beads for biomedical applications

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS

卷:324

Article

Gusenbauer, Markus¹  Kovacs, Alexander¹  Reichel, Franz¹  Exl, Lukas¹  Bance, Simon¹  Oezelt, Harald¹  Schrefl, Thomas¹ 

[1] St Poelten Univ Appl Sci, St Polten, Austria

关键词: Biomedical application;    Magnetic bead;    Particle interaction;    Lab-on-chip;    Yade;    Circulating tumor cell;   

DOI  :  10.1016/j.jmmm.2011.09.034

来源: Elsevier

【 摘 要 】

In the field of biomedicine magnetic beads are used for drug delivery and to treat hyperthermia. Here we propose to use self-organized bead structures to isolate circulating tumor cells using lab-on-chip technologies. Typically blood flows past microposts functionalized with antibodies for circulating tumor cells. Creating these microposts with interacting magnetic beads makes it possible to tune the geometry in size, position and shape. We developed a simulation tool that combines micromagnetics and discrete particle dynamics, in order to design micropost arrays made of interacting beads. The simulation takes into account the viscous drag of the blood flow, magnetostatic interactions between the magnetic beads and gradient forces from external aligned magnets. We developed a particle-particle particle-mesh method for effective computation of the magnetic force and torque acting on the particles. (C) 2011 Elsevier B.V. All rights reserved.

【 授权许可】

Free