Magnetic drug delivery with FePd nano wires

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS

卷:380

Article; Proceedings Paper

Pondman, Kirsten M.¹  Bunt, Nathan D.¹  Maijenburg, A. Wouter²  van Wezel, Richard J. A.³  Kishore, Uday⁴  Abelmann, Leon⁵  ten Elshof, Johan E.²  ten Haken, Bennie¹ 

[1] Univ Twente, MIRA Inst, NL-7500 AE Enschede, Netherlands

[2] Univ Twente, MESA, Inst Nanotechnol, NL-7500 AE Enschede, Netherlands

[3] Univ Twente, MIRA, NL-7500 AE Enschede, Netherlands

[4] Brunel Univ, Ctr Infect Immun & Dis Mech, London, England

[5] Univ Twente, MESA, Inst Nanotechnol, Transducer Sci & Technol Grp, NL-7500 AE Enschede, Netherlands

关键词: Magnetic drug delivery;    Nanowire;    Toxicity;    Immune response;   

DOI  :  10.1016/j.jmmm.2014.10.101

来源: Elsevier

【 摘 要 】

Magnetic drug delivery is a promising method to target a drug to a diseased area while reducing negative side effects caused by systemic administration of drugs. In magnetic drug delivery a therapeutic agent is coupled to a magnetic nanoparticle. The particles are injected and at the target location withdrawn from blood flow by a magnetic field. In this study a Fed nanowire is developed with optimised properties for magnetic targeting. The nanowires have a high magnetic moment to reduce the field gradient needed to capture them vvith a magnet. The dimensions and the materials of the nanowire and coating are such that they are dispersable in aqueous media, non-cytotoxic, easily phagocytosed and not complement activating. This is established in several in vitro tests vvith macrophage and endothelial cell lines. Along with the nanowires a magnet is designed, optimised for capture of the nanowires from the blood flow in the hind leg of a rat. The system is used in a pilot scale in-viva experiment. No negative side effects from injection of the nanowires were found within the limited time span of the experiment. In this first pilot experiment no nanowires were found to be targeted by the magnet, or in the liver, kidneys or spleen, most likely the particles were removed during the fixation procedure. (C) 2015 Elsevier B.V. All rights reserved

【 授权许可】

Free