Numerical simulation of magnetic nano drug targeting in patient-specific lower respiratory tract

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS

卷:451

Article

Russo, Flavia¹  Boghi, Andrea²  Gori, Fabio¹ 

[1] Univ Roma Tor Vergata, Dept Ind Engn, Via Politecn 1, I-00133 Rome, Italy

[2] Cranfield Univ, Sch Water Energy & Environm, Cranfield MK43 0AL, Beds, England

关键词: Magnetic hydro dynamics;    Patient-specific;    Nanoparticles;    Lagrangian model;    Eulerian model;    Lower respiratory tract;   

DOI  :  10.1016/j.jmmm.2017.11.118

来源: Elsevier

【 摘 要 】

Magnetic nano drug targeting, with an external magnetic field, can potentially improve the drug absorption in specific locations of the body. However, the effectiveness of the procedure can be reduced due to the limitations of the magnetic field intensity. This work investigates this technique with the Computational Fluid Dynamics (CFD) approach. A single rectangular coil generates the external magnetic field. A patient-specific geometry of the Trachea, with its primary and secondary bronchi, is reconstructed from Digital Imaging and Communications in Medicine (DICOM) formatted images, throughout the Vascular Modelling Tool Kit (VMTK) software. A solver, coupling the Lagrangian dynamics of the magnetic nanoparticles with the Eulerian dynamics of the air, is used to perform the simulations. The resistive pressure, the pulsatile inlet velocity and the rectangular coil magnetic field are the boundary conditions. The dynamics of the injected particles is investigated without and with the magnetic probe. The flow field promotes particles adhesion to the tracheal wall. The particles volumetric flow rate in both cases has been calculated. The magnetic probe is shown to increase the particles flow in the target region, but at a limited extent. This behavior has been attributed to the small particle size and the probe configuration. (C) 2017 Elsevier B.V. All rights reserved.

【 授权许可】

Free