Hydrazone exchange in nanoparticle monolayers : a dynamic covalent approach for controlling nanomaterial properties

Supramolecular chemistry;Nanoparticles;Gold;Hydrazones

della Sala, Flavio ; Kay, Euan Robert ; Kay, Euan Robert

University:University of St Andrews

Department:Chemistry (School of)

关键词: Supramolecular chemistry;    Nanoparticles;    Gold;    Hydrazones;   

Others  :  https://research-repository.st-andrews.ac.uk/bitstream/handle/10023/6766/FlaviodellaSalaPhDThesis.pdf?sequence=6&isAllowed=y

来源: DR-NTU

【 摘 要 】

This Thesis reports the synthesis, purification and characterisation of goldnanoparticles (NPs) functionalised with a monolayer of hydrazone ligands in order toperform post-synthetic manipulations of the NP-bound monolayer exploiting dynamiccovalent chemistry. NP post-synthetic manipulation based on reversible non-covalentinteractions between oligonucleotides represents a promising approach to achievefunctionalisation and self-assembly for potential applications in biology and medicine.However, the stability of these nanosystems is ensured only in a narrow window ofenvironmental conditions. On the other hand, irreversible covalent strategies potentiallyallow the full range of synthetic chemistry to be exploited but they provide poor controlover the manipulation of the NP-bound monolayer and can only produce kineticallycontrolled amorphous NP aggregates. Dynamic covalent chemistry represents aninteresting and an attractive alternative approach because it would combine thereversibility of non-covalent interactions with the stability of covalent bonds. By thisway, ligand-functionalised NPs could be manipulated in order to introduce a largevariety of molecular functionalities on the NP surface not only to subtly tune the NPphysicochemical properties but also to access an entire range of novel nanomaterials.