Impact of gonadectomy on maturational changes in brain volume in adolescent macaques

PSYCHONEUROENDOCRINOLOGY

卷:124

Article

Knickmeyer, Rebecca C.^1,2  Nguyen, Crystal T.³  Young, Jeffrey T.²  Haunton, Anne^4,11  Kosorok, Michael R.³  Gilmore, John H.²  Styner, Martin^2,5  Rothmond, Debora A.⁶  Noble, Pamela L.⁷  Lenroot, Rhoshel⁸  Weickert, Cynthia Shannon^9,10 

[1] Michigan State Univ, Inst Quantitat Hlth Sci & Engn, Bio Engn Facil, Room 2114,775 Woodlot Dr, E Lansing, MI 48824 USA

[2] Univ North Carolina Chapel Hill, Dept Psychiat, Campus Box 7160, Chapel Hill, NC 27599 USA

[3] Univ North Carolina Chapel Hill, Dept Biostat, Campus Box 7420, Chapel Hill, NC 27599 USA

[4] North Carolina Sch Sci & Math, 1219 Broad St, Durham, NC 27705 USA

[5] Univ North Carolina Chapel Hill, Dept Comp Sci, Campus Box 3175, Chapel Hill, NC 27599 USA

[6] Neurosci Res Australia, Schizophrenia Res Lab, Randwick, NSW 2031, Australia

[7] NIMH, Lab Neuropsychol, NIH, Bethesda, MD 20892 USA

[8] Univ New Mexico, Dept Psychiat & Behav Sci, Albuquerque, NM 87131 USA

[9] Univ New South Wales, Fac Med, Sch Psychiat, Sydney, NSW 2052, Australia

[10] Upstate Med Univ, Dept Neurosci & Physiol, Syracuse, NY 13210 USA

[11] North Carolina State Univ, Raleigh, NC 27695 USA

关键词: Macaca mulatta;    Adolescent;    Prefrontal cortex;    Magnetic resonance imaging;    Testosterone;   

DOI  :  10.1016/j.psyneuen.2020.105068

来源: Elsevier

【 摘 要 】

Adolescence is a transitional period between childhood and adulthood characterized by significant changes in global and regional brain tissue volumes. It is also a period of increasing vulnerability to psychiatric illness. The relationship between these patterns and increased levels of circulating sex steroids during adolescence remains unclear. The objective of the current study was to determine whether gonadectomy, prior to puberty, alters adolescent brain development in male rhesus macaques. Ninety-six structural MRI scans were acquired from 12 male rhesus macaques (8 time points per animal over a two-year period). Six animals underwent gonadectomy and 6 animals underwent a sham operation at 29 months of age. Mixed-effects models were used to determine whether gonadectomy altered developmental trajectories of global and regional brain tissue volumes. We observed a significant effect of gonadectomy on the developmental trajectory of prefrontal gray matter (GM), with intact males showing peak volumes around 3.5 years of age with a subsequent decline. In contrast, prefrontal GM volumes continued to increase in gonadectomized males until the end of the study. We did not observe a significant effect of gonadectomy on prefrontal white matter or on any other global or regional brain tissue volumes, though we cannot rule out that effects might be detected in a larger sample. Results suggest that the prefrontal cortex is more vulnerable to gonadectomy than other brain regions.

【 授权许可】

Free