Concordance Between BeamF3 and MRI-neuronavigated Target Sites for Repetitive Transcranial Magnetic Stimulation of the Left Dorsolateral Prefrontal Cortex

Brain Stimulation

Zafiris J. Daskalakis¹  Peter Fried²  Peter Giacobbe³  Ruth Caballero⁴  Katherine Lee⁴  Michael D. Fox⁴  Jonathan Downar⁵  Daniel M. Blumberger⁶  Arsalan Mir-Moghtadaei⁶ 

[1] Athinoula A. Martinos Center for Biomedical Imaging, Harvard Medical School, Boston, MA, USA;Bioengineering and Telemedicine Centre, ETSI Telecomunicación, Universidad Politécnica de Madrid, Spain;Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA;Berenson-Allen Center for Noninvasive Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA;Department of Psychiatry, University of Toronto, Canada;Faculty of Arts and Sciences, University of Toronto, Canada;

关键词: Neuronavigation;    Prefrontal cortex;    Transcranial magnetic stimulation;    Magnetic resonance imaging;    Scalp;   

DOI  :  

来源: DOAJ

【 摘 要 】

Background: The dorsolateral prefrontal cortex (DLPFC) is a common target for repetitive transcranial magnetic stimulation (rTMS) in major depression, but the conventional “5 cm rule” misses DLPFC in >1/3 cases. Another heuristic, BeamF3, locates the F3 EEG site from scalp measurements. MRI-guided neuronavigation is more onerous, but can target a specific DLPFC stereotaxic coordinate directly. The concordance between these two approaches has not previously been assessed. Objective: To quantify the discrepancy in scalp site between BeamF3 versus MRI-guided neuronavigation for left DLPFC. Methods: Using 100 pre-treatment MRIs from subjects undergoing left DLPFC-rTMS, we localized the scalp site at minimum Euclidean distance from a target MNI coordinate (X − 38 Y + 44 Z + 26) derived from our previous work. We performed nasion-inion, tragus–tragus, and head-circumference measurements on the same subjects' MRIs, and applied the BeamF3 heuristic. We then compared the distance between BeamF3 and MRI-guided scalp sites. Results: BeamF3-to-MRI-guided discrepancies were <0.65 cm in 50% of subjects, <0.99 cm in 75% of subjects, and <1.36 cm in 95% of subjects. The angle from midline to the scalp site did not differ significantly using MRI-guided versus BeamF3 methods. However, the length of the radial arc from vertex to target site was slightly but significantly longer (mean 0.35 cm) with MRI-guidance versus BeamF3. Conclusions: The BeamF3 heuristic may provide a reasonable approximation to MRI-guided neuronavigation for locating left DLPFC in a majority of subjects. A minor optimization of the heuristic may yield additional concordance.

【 授权许可】

Unknown