' Unilateral repetitive transcranial magnetic stimulation differentially affects younger and older adults completing a verbal working memory task

JOURNAL OF THE NEUROLOGICAL SCIENCES

卷:384

Article

Shields, Jessica¹  Mock, Jeffrey²  Devier, Deidre³  Foundas, Anne⁴ 

[1] Louisiana State Univ, Hlth Sci Ctr, Dept Neurosurg, New Orleans, LA 70112 USA

[2] Univ Texas San Antonio, Dept Psychol, San Antonio, TX 78249 USA

[3] Louisiana State Univ, Dept Neurol, Hlth Sci Ctr, New Orleans, LA 70112 USA

[4] Louisiana State Univ, Dept Commun Sci & Disorders, Brain Inst Louisiana, Baton Rouge, LA 70803 USA

关键词: Transcranial magnetic stimulation;    Aging;    Working memory;    Prefrontal cortex;    Compensation;   

DOI  :  10.1016/j.jns.2017.10.021

来源: Elsevier

【 摘 要 】

Functional neuroimaging studies have found that lateralization of activity in the dorsolateral prefrontal cortex (dIPFC) is reduced with aging. In the present study, repetitive transcranial magnetic stimulation (rTMS) was used to disrupt dIPFC activity in order to test the relationship of dIPFC laterality and age in verbal working memory (WM). Young (n = 36) and older (n = 35) subjects received 1 Hz-rTMS (sham or active) to left or right dIPFC and WM performance was assessed pre- and post-stimulation via the n-back task. Significant increases in WM accuracy were observed following rTMS in the right dIPFC and sham conditions, but not with the left dIPFC stimulation. This was accompanied by a decrease in left P1 latency was also observed following left dIPFC stimulation. In contrast, older adults did not show a disruption in WM performance following rTMS in any of the stimulation conditions and exhibited increased left P3 amplitude following left stimulation. Our results show that changes in prefrontal laterality are evident with increasing age (left stimulation affects younger adults while older adults are not affected by stimulation) and this change is associated with specific neurophysiologic measures.

【 授权许可】

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