Increased interleukin 18 activity in adolescents with early-onset psychosis is associated with cortisol and depressive symptoms

PSYCHONEUROENDOCRINOLOGY

卷:112

Article

Wedervang-Resell, Kirsten^1,3  Friis, Svein^3,2  Lonning, Vera^1,4  Smelror, Runar E.^1,4  Johannessen, Cecilie^1,4  Reponen, Elina J.¹  Lyngstad, Siv H.¹  Lekva, Tove⁷  Aukrust, Pal^7,8,2  Ueland, Thor^7,9,2  Andreassen, Ole A.¹  Agartz, Ingrid^1,4,5  Myhre, Anne M.^3,6 

[1] Univ Oslo, Oslo Univ Hosp, NORMENT, Div Mental Hlth & Addict, Oslo, Norway

[2] Univ Oslo, Inst Clin Med, Oslo, Norway

[3] Oslo Univ Hosp, Div Mental Hlth & Addict, Dept Psychiat Res & Dev, Oslo, Norway

[4] Diakonhjemmet Hosp, Dept Psychiat Res, Oslo, Norway

[5] Karolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res, Stockholm, Sweden

[6] Univ Oslo, Inst Clin Med, Div Mental Hlth & Addict, Child & Adolescent Psychiat Unit, Oslo, Norway

[7] Oslo Univ Hosp, Rikshosp, Internal Med Res Inst, Oslo, Norway

[8] Oslo Univ Hosp, Rikshosp, Sect Clin Immunol & Infect Dis, Oslo, Norway

[9] Univ Tromso, KG Jebsen Thrombosis Res & Expertise Ctr, Tromso, Norway

关键词: Cortisol;    Immune system;    Cytokines;    Inflammation;    IL-18;   

DOI  :  10.1016/j.psyneuen.2019.104513

来源: Elsevier

【 摘 要 】

Objective: Evidence indicates that the pathophysiology of adult psychosis involves immune dysregulation, but its associations with stress are often not considered. The inflammatory cytokine interleukin (IL)-18, which is elevated in adult schizophrenia, is suggested to be sensitive to stress. We compared the associations of IL-18 with cortisol and clinical variables in adolescents with early-onset psychosis (EOP) aged 12-18 years and age-matched healthy controls (HC). Method: We measured serum IL-18, IL-18 binding protein (IL-18BP), IL-18 receptor accessory protein (IL-18RAP), IL-18 receptor 1 (IL-18R1) and cortisol, and calculated the IL-18/IL-18BP ratio in patients (n = 31) and HC (n = 60). Psychotic symptoms were assessed using the Positive and Negative Syndrome Scale and depressive symptoms by the Mood and Feelings Questionnaire-Child version (MFQ-C). Bivariate correlation analysis was used to explore relationships between IL-18/IL-18BP ratio and cortisol, depression and other clinical characteristics. Hierarchical multiple linear regression analysis was used to assess their individual contributions to the variance of the IL-18/IL-18BP ratio. Results: Patients had significantly higher IL-18 levels and IL-18/IL-18BP ratios than HC, but similar IL-18BP, IL-18RAP and IL-18R1. Both cortisol (R-2 change = 0.05) and the MFQ-C score (R-2 change = 0.09) contributed significantly to the variance in IL-18/IL-18BP ratios after controlling for confounders. Conclusion: We found increased IL-18 system activity in adolescents with EOP. Cortisol and depressive symptoms each contributed to the variance in the IL-18/IL-18BP ratio. Our findings support activation of inflammatory pathways in adolescent psychosis and suggest interactions between stress, inflammation and depressive symptoms in EOP.

【 授权许可】

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