Lateral spread of dose distribution by therapeutic proton beams in liquid water

NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS

卷:352

Article

Abril, Isabel¹  de Vera, Pablo¹  Garcia-Molina, Rafael²  Kyriakou, Ioanna³  Emfietzoglou, Dimitris³ 

[1] Univ Alicante, Dept Fis Aplicada, E-03080 Alicante, Spain

[2] Univ Murcia, Dept Fis, Ctr Invest Opt & Nanofis, E-30100 Murcia, Spain

[3] Univ Ioannina, Sch Med, Med Phys Lab, GR-45110 Ioannina, Greece

关键词: Hadron therapy;    Proton beam;    Bragg peak;    Liquid water;    Depth-dose profile;   

DOI  :  10.1016/j.nimb.2014.11.100

来源: Elsevier

【 摘 要 】

We have calculated the lateral spread of the dose distribution of protons in liquid water by means of the SEICS (Simulation of Energetic Ions and Clusters through Solids) code, which properly accounts for the electronic stopping force (including energy-loss straggling), multiple elastic scattering with the target nuclei, dynamical electron charge-exchange processes and nuclear fragmentation reactions between the projectile and the nuclei of the target. Due to the multiple elastic scattering processes part of the proton energy may be deposited at a given lateral distance from the initial beam direction, which is quantified by the root mean square radius (r(rms)). We find in our simulations that the r(rms) follows a parabolic dependence as a function of the depth in the target and the quotient between the r(rms) at the Bragg peak and the depth of the Bragg peak is around 3% independently of the proton energy. A rather good agreement is obtained when comparing our results of r(rms) with experimental data and with other models. (C) 2014 Elsevier B.V. All rights reserved.

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