Geant4 Monte Carlo simulation of absorbed dose and radiolysis yields enhancement from a gold nanoparticle under MeV proton irradiation

NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS

卷:373

Article

Tran, H. N.^1,2  Karamitros, M.³  Ivanchenko, V. N.⁴  Guatelli, S.^5,6  McKinnon, S.^5,6  Murakami, K.⁷  Sasaki, T.⁷  Okada, S.⁷  Bordage, M. C.^8,9  Francis, Z.¹⁰  El Bitar, Z.¹¹  Bernal, M. A.¹²  Shin, J. I.¹³  Lee, S. B.¹⁴  Barberet, Ph.^15,16  Tran, T. T.¹⁷  Brown, J. M. C.¹⁸  Hao, T. V. Nhan^19,20  Incerti, S.^1,2,15,16 

[1] Ton Duc Thang Univ, Div Nucl Phys, Tan Phong Ward, Dist 7, Ho Chi Minh City, Vietnam

[2] Ton Duc Thang Univ, Fac Sci Appl, Tan Phong Ward, Dist 7, Ho Chi Minh City, Vietnam

[3] Univ Notre Dame, Notre Dame Radiat Lab, Notre Dame, IN 46556 USA

[4] Geant4 Associates Int Ltd, Hebden Bridge, England

[5] Univ Wollongong, Ctr Med Radiat Phys, Wollongong, NSW 2522, Australia

[6] Univ Wollongong, Illawarra Hlth & Med Res, Wollongong, NSW 2522, Australia

[7] High Energy Accelerator Org, KEK, Ctr Res Comp, 1-1 Oho, Tsukuba, Ibaraki 3050801, Japan

[8] INSERM, UMR 1037, CRCT, F-31000 Toulouse, France

[9] Univ Toulouse 3, UMR 1037, CRCT, F-31000 Toulouse, France

[10] St Joseph Univ, Fac Sci, Dept Phys, Beirut, Lebanon

[11] CNRS, IN2P3, Inst Pluridisciplinaire Hubert Curien, Strasbourg, France

[12] Univ Estadual Campinas, Inst Fis Gleb Wataghin, BR-13081970 Campinas, SP, Brazil

[13] Korea Inst Radiol & Med Sci, Div Heavy Ion Clin Res, 75 Nowon Ro, Seoul, South Korea

[14] Natl Canc Ctr, Proton Therapy Ctr, 323 Ilsan Ro, Goyang Si, Gyeonggi Do, South Korea

[15] Univ Bordeaux, CENBG, UMR 5797, F-33170 Gradignan, France

[16] CNRS, IN2P3, CENBG, UMR 5797, F-33170 Gradignan, France

[17] VNUHCM Univ Sci, Hanoi, Vietnam

[18] Queens Univ Belfast, Sch Math & Phys, Belfast, Antrim, North Ireland

[19] Duy Tan Univ, Ctr Res & Dev, K7-25 Quang Trung, Danang, Vietnam

[20] Texas A&M Univ Commerce, Dept Phys & Astron, Commerce, TX 75429 USA

关键词: Geant4-DNA;    Nanoparticle;    Radiolysis;    Proton beam;    Radiation therapy;   

DOI  :  10.1016/j.nimb.2016.01.017

来源: Elsevier

【 摘 要 】

Gold nanoparticles have been reported as a possible radio-sensitizer agent in radiation therapy due to their ability to increase energy deposition and subsequent direct damage to cells and DNA within their local vicinity. Moreover, this increase in energy deposition also results in an increase of the radiochemical yields. In this work we present, for the first time, an in silico investigation, based on the general purpose Monte Carlo simulation toolkit Geant4, into energy deposition and radical species production around a spherical gold nanoparticle 50 nm in diameter via proton irradiation. Simulations were preformed for incident proton energies ranging from 2 to 170 MeV, which are of interest for clinical proton therapy. (C) 2016 Elsevier B.V. All rights reserved.

【 授权许可】

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