Endurance exercise-induced changes in BNP concentrations in cardiovascular patients versus healthy controls

INTERNATIONAL JOURNAL OF CARDIOLOGY

卷:227

Article

Aengevaeren, Vincent L.^1,2  Hopman, Maria T. E.¹  Thijssen, Dick H. J.^1,3  van Kimmenade, Roland R.²  de Boer, Menko-Jan²  Eijsvogels, Thijs M. H.^1,3 

[1] Radboud Univ Nijmegen, Radboud Inst Hlth Sci, Dept Physiol, Med Ctr, Nijmegen, Netherlands

[2] Radboud Univ Nijmegen, Radboud Inst Hlth Sci, Dept Cardiol, Med Ctr, Nijmegen, Netherlands

[3] Liverpool John Moores Univ, Res Inst Sport & Exercise Sci, Liverpool, Merseyside, England

关键词: Walking;    Biomarkers;    Cardiovascular diseases;    Risk factors;   

DOI  :  10.1016/j.ijcard.2016.11.016

来源: Elsevier

【 摘 要 】

Background: Healthy athletes demonstrated increased B-type natriurelic peptide (BNP) concentrations following exercise, but it is unknown whether these responses are exaggerated in individuals with cardiovascular risk factors (CVRF) or disease (CVD). We compared exercise-induced increases in BNP between healthy controls (CON) and individuals with CVRF or CVD. Furthermore, we aimed to identify predictors for BNP responses. Methods: Scrum BNP concentrations were measured in 191 participants (60 +/- 12 yrs) of the Nijmegen Marches before (baseline) and immediately after 4 consecutive days of walking exercise (30-50 km/day). CVRF (n = 54) was defined as hypertension, hypercholesterolemia, obesity Of smoking and CVD (n = 55) was defined as a history of 'myocardial 'infarction, heart failure, atrial fibrillation or angina pectoris. Results: Individuals walked 487 +/- 79 min/day at 65 +/- 10% of their 'maximum heart rate. Baseline BNP concentrations were higher for CVD (median: 28.1 pg/ml; interquartile range: 13-50, p < 0.001) compared to CVRF (3.9 pg/ml; 0-14) and CON (5.5 pg/ml; 0-14). Post-exercise BNP concentrations were elevated in CVD (35.7 pg/ml, 17-67, p = 0.01), but not in CVRF participants (p = 0.11) or CON (p = 0.07). No cumulative effect in BNP concentrations was observed across the consecutive walking days (p > 0.05). Predictors for post-exercise BNP 0.77) were baseline BNP, beta-blocker use and age. Conclusion: Prolonged moderate-intensity walking exercise increases BNP concentrations in CVD participants, but not in CVRF and CON. BNP increases were small and did not accumulate across consecutive clays of exercise. These findings suggest that prolonged walking exercise for multiple consecutive clays is feasible with minimal effect on myocardial stretch, even for participants with CVD. (C) 2016 The Authors. Published by Elsevier Ireland Ltd.

【 授权许可】

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