Association of maternal dietary intakes and CBS gene polymorphisms with congenital heart disease in offspring

INTERNATIONAL JOURNAL OF CARDIOLOGY

卷:322

Article

Li, Yihuan¹  Diao, Jingyi¹  Li, Jinqi¹  Luo, Liu¹  Zhao, Lijuan¹  Zhang, Senmao¹  Wang, Tingting¹  Chen, Letao¹  Yang, Tubao¹  Chen, Lizhang^1,2  Zhu, Ping⁴  Qin, Jiabi^1,2,3,4 

[1] Cent South Univ, Xiangya Sch Publ Hlth, Dept Epidemiol & Hlth Stat, 110 Xiangya Rd, Changsha 410078, Hunan, Peoples R China

[2] Hunan Prov Key Lab Clin Epidemiol, Changsha, Hunan, Peoples R China

[3] Natl Hlth Commiss Key Lab Birth Defect Res & Prev, Changsha, Hunan, Peoples R China

[4] Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Guangdong Cardiovasc Inst, 106 ZhongshanEr Rd, Guangzhou 510100, Guangdong, Peoples R China

关键词: Congenital heart disease;    Cystathionine beta-synthase gene;    Dietary intakes;    Case-control study;    Interaction effects;   

DOI  :  10.1016/j.ijcard.2020.08.018

来源: Elsevier

【 摘 要 】

Background: Although it is generally acknowledged that genetic and environmental factors are associated with risk of congenital heart disease (CHD), the causes are not fully understood. This study aimed at assessing the association of maternal dietary intakes, genetic variants of cystathionine beta synthase (CBS) gene and their interactions with risk of CHDs in offspring. Method: A hospital-based case-control study of 464 mothers with CHD infants and 504 control mothers of health infant was performed. The exposures of interest were maternal dietary intakes in early pregnancy, single nucleotide polymorphisms (SNPs) of CBS gene. Results: More frequent intake of pickled vegetables (adjusted odds ratio[aOR] = 1.81; 95% confidence interval [CI]: 1.38-2.37), smoked foods (aOR = 2.00; 95%CI: 1.53-2.60), barbecued foods (aOR = 1.63; 95%CI: 1.19-2.25) and fried foods (aOR = 1.57; 95%CI: 1.22-2.03) were associated with higher risk of CHD, while salted eggs (aOR = 0.20; 95%CI: 0.12-0.33), fish and shrimp (aOR = 0.34; 95%CI: 0.27-0.44), fresh fruits (aOR = 0.49; 95%CI: 0.37-0.66), and milk products (aOR = 0.54; 95%CI: 0.45-0.65) were associated with lower risk of CHD. The SNPs of CBS gene at rs2851391 (T/T vs C/C: aOR = 1.91, 95%CI: 1.15-3.15) and rs234714 (T/T vs C/C: aOR = 2.22, 95%CI: 1.32-3.73) significantly increased the risk of CHD. Additionally, significant interaction effects between maternal dietary intakes and CBS genetic variants on CHD risks were observed. Conclusions: Maternal dietary factors, CBS genetic variants and their interactions were significantly associated with risk of CHD in offspring. However, it is still unclear how these factors jointly work in the development of CHD, and more studies with larger samples and prospective design are required. (C) 2020 Elsevier B.V. All rights reserved.

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