The risk of infection and malignancy with tumor necrosis factor antagonists in adults with psoriatic disease: A systematic review and meta-analysis of randomized controlled trials

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

卷:64

Review

Dommasch, Erica D.^2,4  Abuabara, Katrina^2,5  Shin, Daniel B.²  Josephine Nguyen²  Troxel, Andrea B.^1,3  Gelfand, Joel M.^1,2,3 

[1] Univ Penn, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USA

[2] Univ Penn, Dept Dermatol, Philadelphia, PA 19104 USA

[3] Univ Penn, Ctr Clin Epidemiol & Biostat, Philadelphia, PA 19104 USA

[4] Penn Hosp, Dept Internal Med, Philadelphia, PA 19107 USA

[5] Hosp Univ Penn, Dept Internal Med, Philadelphia, PA 19104 USA

关键词: biologics;    cancer;    infection;    malignancy;    meta-analysis;    psoriasis;    psoriatic arthritis;    safety;    tumor necrosis factor-alfa;   

DOI  :  10.1016/j.jaad.2010.09.734

来源: Elsevier

【 摘 要 】

Background: There is a need to better understand the safety of tumor necrosis factor (TNF) inhibitors in patients with psoriatic disease in whom TNF inhibitors are frequently used as monotherapy. Objective: We sought to examine the risks of infection and malignancy with the use of TNF antagonists in adult patients with psoriatic disease. Methods: We conducted a systematic search for trials of TNF antagonists for adults with plaque psoriasis and psoriatic arthritis. We included randomized, placebo-controlled trials of etanercept, infliximab, adalimumab, golimumab, and certolizumab for the treatment of plaque psoriasis and psoriatic arthritis. Twenty of 820 identified studies with a total of 6810 patients were included. Results were calculated using fixed effects models and reported as pooled odds ratios. Results: Odds ratios for overall infection and serious infection over a mean of 17.8 weeks were 1.18 (95% confidence interval [CI] 1.05-1.33) and 0.70 (95% CI 0.40-1.21), respectively. When adjusting for patient-years, the incidence rate ratio for overall infection was 1.01 (95% CI 0.92-1.11). The odds ratio for malignancy was 1.48 (95% CI 0.71-3.09) and 1.26 (95% CI 0.39-4.15) when nonmelanoma skin cancer was excluded. Limitations: Short duration of follow-up and rarity of malignancies and serious infections are limitations. Conclusions:There is a small increased risk of overall infection with the short-term use of TNF antagonists for psoriasis that may be attributable to differences in follow-up time between treatment and placebo groups. There was no evidence of an increased risk of serious infection and a statistically significant increased risk in cancer was not observed with short-term use of TNF inhibitors. (J Am Acad Dermatol 2011;64:1035-50.)

【 授权许可】

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