The Alzheimer's Disease Amyloid-Beta Hypothesis in Cardiovascular Aging and Disease JACC Focus Seminar

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

卷:75

Review

Stakos, Dimitrios A.¹  Stamatelopoulos, Kimon^2,3  Bampatsias, Dimitrios²  Sachse, Marco^3,4  Zormpas, Eleftherios³  Vlachogiannis, Nikolaos I.³  Tual-Chalot, Simon³  Stellos, Konstantinos^3,5,6,7 

[1] Democritus Univ Thrace, Cardiol Dept, Alexandroupolis, Greece

[2] Natl & Kapodistrian Univ Athens, Dept Clin Therapeut, Sch Med, Athens, Greece

[3] Newcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, England

[4] Goethe Univ Frankfurt, Med Sch, Frankfurt, Germany

[5] Newcastle Hosp NHS Fdn Trust, Freeman Hosp, Dept Cardiol, Newcastle Upon Tyne, Tyne & Wear, England

[6] Newcastle Univ, NIHR Newcastle Biomed Res Ctr, Newcastle Upon Tyne, Tyne & Wear, England

[7] Newcastle upon Tyne NHS Fdn Trust, Newcastle Upon Tyne, Tyne & Wear, England

关键词: Alzheimer's disease;    amyloid-beta;    amyloid precursor protein;    atherosclerosis;    cardiovascular disease;    cardiovascular therapy;    cerebral amyloid angiopathy;    coronary artery disease;    endothelial cells;    leukocytes;    platelets;    prognosis;    vascular dementia;    vascular stiffness;   

DOI  :  10.1016/j.jacc.2019.12.033

来源: Elsevier

【 摘 要 】

Aging-related cellular and molecular processes including low-grade inflammation are major players in the pathogenesis of cardiovascular disease (CVD) and Alzheimer's disease (AD). Epidemiological studies report an independent interaction between the development of dementia and the incidence of CVD in several populations, suggesting the presence of overlapping molecular mechanisms. Accumulating experimental and clinical evidence suggests that amyloid-beta (A beta) peptides may function as a link among aging, CVD, and AD. Aging-related vascular and cardiac deposition of A beta induces tissue inflammation and organ dysfunction, both important components of the Alzheimer's disease amyloid hypothesis. In this revie w, the authors describe the determinants of A beta metabolism, summarize the effects of A beta on atherothrombosis and cardiac dysfunction, discuss the clinical value of A beta 1-40 in CVD prognosis and patient risk stratification, and present the therapeutic interventions that may alter A beta metabolism in humans. (C) 2020 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.

【 授权许可】

Free