Adherence to Healthy Lifestyle and Cardiovascular Diseases in the Chinese Population

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

卷:69

Article

Lv, Jun^1,2  Yu, Canqing¹  Guo, Yu³  Bian, Zheng³  Yang, Ling^4,5  Chen, Yiping^4,5  Tang, Xuefeng⁶  Zhang, Weiyuan⁷  Qian, Yijian⁸  Huang, Yuelong⁹  Wang, Xiaoping¹⁰  Chen, Junshi¹¹  Chen, Zhengming^4,5  Qi, Lu^12,13  Li, Liming^1,3 

[1] Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing, Peoples R China

[2] Peking Univ, Inst Environm Med, Beijing, Peoples R China

[3] Chinese Acad Sci, Beijing, Peoples R China

[4] Univ Oxford, Nuffield Dept Populat Hlth, Clin Trial Serv Unit, Oxford, England

[5] Univ Oxford, Nuffield Dept Populat Hlth, Epidemiol Studies Unit CTSU, Oxford, England

[6] Sichuan Ctr Dis Control & Prevent, Chengdu, Sichuan, Peoples R China

[7] Liuzhou Ctr Dis Control & Prevent, Liuzhou, Guangxi, Peoples R China

[8] Tongxiang Ctr Dis Control & Prevent, Tongxiang, Zhejiang, Peoples R China

[9] Hunan Ctr Dis Control & Prevent, Changsha, Hunan, Peoples R China

[10] Maiji Ctr Dis Control & Prevent, Tianshui, Gansu, Peoples R China

[11] China Natl Ctr Food Safety Risk Assessment, Beijing, Peoples R China

[12] Tulane Univ, Sch Publ Hlth & Trop Med, Dept Epidemiol, 1440 Canal St,Suite 1724, New Orleans, LA 70112 USA

[13] Harvard Sch Publ Hlth, Dept Nutr, Boston, MA USA

关键词: cardiovascular diseases;    cohort studies;    health behavior;    lifestyle;   

DOI  :  10.1016/j.jacc.2016.11.076

来源: Elsevier

【 摘 要 】

BACKGROUND Adherence to a combination of healthy lifestyle factors has been related to a considerable reduction of cardiovascular risk in white populations; however, little is known whether such associations persist in nonwhite populations like the Asian population. OBJECTIVES This study aimed to examine the associations of a combination of modifiable, healthy lifestyle factors with the risks of ischemic cardiovascular diseases and estimate the proportion of diseases that could potentially be prevented by adherence to these healthy lifestyle patterns. METHODS This study examined the associations of 6 lifestyle factors with ischemic heart disease and ischemic stroke (IS) in the China Kadoorie Biobank of 461,211 participants 30 to 79 years of age who did not have cardiovascular diseases, cancer, or diabetes at baseline. Low-risk lifestyle factors were defined as nonsmoking status or having stopped smoking for reasons other than illness, alcohol consumption of <30 g/day, a median or higher level of physical activity, a diet rich in vegetables and fruits and limited in red meat, a body mass index of 18.5 to 23.9 kg/m(2), and a waist-to-hip ratio <0.90 for men and <0.85 for women. RESULTS During a median of 7.2 years (3.3 million person-years) of follow-up, this study documented 3,331 incident major coronary events (MCE) and 19,348 incident ISs. In multivariable-adjusted analyses, current nonsmoking status, light to moderate alcohol consumption, high physical activity, a diet rich in vegetables and fruits and limited in red meat, and low adiposity were independently associated with reduced risks of MCE and IS. Compared with participants without any low-risk factors, the hazard ratio for participants with >= 4 low-risk factors was 0.42 (95% confidence interval: 0.34 to 0.52) for MCE and 0.61 (95% confidence interval: 0.56 to 0.66) for IS. Approximately 67.9% (95% confidence interval: 46.5% to 81.9%) of the MCE and 39.1% (95% confidence interval: 26.4% to 50.4%) of the IS cases were attributable to poor adherence to healthy lifestyle. CONCLUSIONS Adherence to healthy lifestyle may substantially lower the burden of cardiovascular diseases in Chinese. (C) 2017 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.

【 授权许可】

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