Evening chronotype is associated with elevated biomarkers of cardiometabolic risk in the EpiHealth cohort: a cross-sectional study

Sleep

article

Baldanzi, Gabriel¹  Hammar, Ulf¹  Fall, Tove¹  Lindberg, Eva²  Lind, Lars³  Elmståhl, Sölve⁴  Theorell-Haglöw, Jenny¹ 

[1] Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University;Department of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala University;Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University;Department of Clinical Sciences, Malmö, Division of Geriatric Medicine, Lund University;CRC, Skåne University Hospital

关键词: chronotype;    sleep habits;    proteomics;    cohort studies;    cardiovascular diseases;    metabolic diseases;   

DOI  :  10.1093/sleep/zsab226

学科分类：生理学

来源: American Academy of Sleep Medicine

【 摘 要 】

Study Objectives Individuals with evening chronotype have a higher risk of cardiovascular and metabolic disorders, although the underlying mechanisms are not well understood. In a population-based cohort, we aimed to investigate the association between chronotype and 242 circulating proteins from three panels of established or candidate biomarkers of cardiometabolic processes.Methods In 2,471 participants (49.7% men, mean age 61.2 ± 8.4 SD years) from the EpiHealth cohort, circulating proteins were analyzed with a multiplex proximity extension technique. Participants self-reported their chronotype on a five-level scale from extreme morning to extreme evening chronotype. With the intermediate chronotype set as the reference, each protein was added as the dependent variable in a series of linear regression models adjusted for confounders. Next, the chronotype coefficients were jointly tested and the resulting p-values adjusted for multiple testing using a false discovery rate (5%). For the associations identified, we then analyzed the marginal effect of each chronotype category.Results We identified 17 proteins associated with chronotype. Evening chronotype was positively associated with proteins previously linked to insulin resistance and cardiovascular risk, namely retinoic acid receptor protein 2, fatty acid-binding protein adipocyte, tissue-type plasminogen activator, and plasminogen activator inhibitor 1 (PAI-1). Additionally, PAI-1 was inversely associated with the extreme morning chronotype.Conclusions In this population-based study, proteins previously related to cardiometabolic risk were elevated in the evening chronotypes. These results may guide future research in the relation between chronotype and cardiometabolic disorders.

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