Early-Life Environmental Exposures and Blood Pressure in Children

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

卷:74

Article

Warembourg, Charline^1,2,3  Maitre, Lea^1,2,3  Tamayo-Uria, Ibon^1,2,3  Fossati, Serena^1,2,3  Roumeliotaki, Theano⁴  Aasvang, Gunn Marit⁵  Andrusaityte, Sandra⁶  Casas, Maribel^1,2,3  Cequier, Enrique⁵  Chatzi, Lida^4,7,8  Dedele, Audrius⁶  Gonzalez, Juan-Ramon^1,2,3  Grazuleviciene, Regina⁶  Haug, Line Smastuen⁵  Hernandez-Ferrer, Carles^1,2,3  Heude, Barbara⁹  Karachaliou, Marianna⁴  Krog, Norun Hjertager⁵  McEachan, Rosemary¹⁰  Nieuwenhuijsen, Mark^1,2,3  Petraviciene, Inga⁶  Quentin, Joane^11,12  Robinson, Oliver¹³  Sakhi, Amrit Kaur⁵  Slama, Remy¹¹  Thomsen, Cathrine⁵  Urquiza, Jose^1,2,3  Vafeiadi, Marina⁴  West, Jane¹⁰  Wright, John¹⁰  Vrijheid, Martine^1,2,3  Basagana, Xavier^1,2,3 

[1] ISGlobal, Doctor Aiguader 88, Barcelona 08003, Spain

[2] UPF, Barcelona, Spain

[3] CIBER Epidemiol & Salud Publ, Madrid, Spain

[4] Univ Crete, Fac Med, Dept Social Med, Iraklion, Greece

[5] Norwegian Inst Publ Hlth, Oslo, Norway

[6] Vytauto Didziojo Univ, Kaunus, Lithuania

[7] Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA USA

[8] Maastricht Univ, Fac Hlth Med & Life Sci, Dept Genet & Cell Biol, Maastricht, Netherlands

[9] Paris Descartes Univ, Epidemiol & Biostat Sorbonne Paris Cite Ctr CRESS, Early ORigins Childs Hlth & Dev Team ORCHAD, INSERM,UMR1153, Paris, France

[10] Bradford Teaching Hosp NHS Fdn Trust, Bradford Inst Hlth Res, Bradford, W Yorkshire, England

[11] Univ Grenoble Alpes, Team Environm Epidemiol Appl Reprod & Resp Hlth, CNRS, Inst Adv Biosci,Inserm, Grenoble, France

[12] CHU Grenoble Alpes, Grenoble, France

[13] Imperial Coll London, MRC PHE Ctr Environm & Hlth, Sch Publ Hlth, London, England

关键词: blood pressure;    chemicals;    children;    cohort;    environment;    epidemiology;    exposome;   

DOI  :  10.1016/j.jacc.2019.06.069

来源: Elsevier

【 摘 要 】

BACKGROUND Growing evidence exists about the fetal and environmental origins of hypertension, but mainly limited to single-exposure studies. The exposome has been proposed as a more holistic approach by studying many exposures simultaneously. OBJECTIVES This study aims to evaluate the association between a wide range of prenatal and postnatal exposures and blood pressure (BP) in children. METHODS Systolic and diastolic BP were measured among 1,277 children from the European HELIX (Human Early-Life Exposome) cohort aged 6 to 11 years. Prenatal (n = 89) and postnatal (n = 128) exposures include air pollution, built environment, meteorology, natural spaces, traffic, noise, chemicals, and lifestyles. Two methods adjusted for confounders were applied: an exposome-wide association study considering the exposures independently, and the deletion-substitution-addition algorithm considering all the exposures simultaneously. RESULTS Decreases in systolic BP were observed with facility density (beta change for an interquartile-range increase in exposure: -1.7 mm Hg [95% confidence interval (CI): -2.5 to -0.8 mm Hg]), maternal concentrations of polychlorinated biphenyl 118 (-1.4 mm Hg [95% CI: -2.6 to -0.2 mm Hg]) and child concentrations of dichlorodiphenyldichloroethylene (DDE: -1.6 mm Hg [95% CI: -2.4 to -0.7 mm Hg]), hexachlorobenzene (-1.5 mm Hg [95% CI: -2.4 to -0.6 mm Hg]), and mono -benzyl phthalate (-0.7 mm Hg [95% CI: -1.3 to -0.1 mm Hg]), whereas increases in systolic BP were observed with outdoor temperature during pregnancy (1.6 mm Hg [95% CI: 0.2 to 2.9 mm Hg]), high fish intake during pregnancy (2.0 mm Hg [95% CI: 0.4 to 3.5 mm Hg]), maternal cotinine concentrations (1.2 mm Hg [95% CI: -0.3 to 2.8 mm Hg]), and child perfluorooctanoate concentrations (0.9 mm Hg [95% CI: 0.1 to 1.6 mm Hg]). Decreases in diastolic BP were observed with outdoor temperature at examination (-1.4 mm Hg [95% CI: -2.3 to -0.5 mm Hg]) and child DDE concentrations (-1.1 mm Hg [95% CI: -1.9 to -0.3 mm Hg]), whereas increases in diastolic BP were observed with maternal bisphenol-A concentrations (0.7 mm Hg [95% CI: 0.1 to 1.4 mm Hg]), high fish intake during pregnancy (1.2 mm Hg [95% CI: -0.2 to 2.7 mm Hg]), and child copper concentrations (0.9 mm Hg [95% CI: 0.3 to 1.6 mm Hg]). CONCLUSIONS This study suggests that early-life exposure to several chemicals, as well as built environment and meteorological factors, may affect BP in children. (C) 2019 by the American College of Cardiology Foundation.

【 授权许可】

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