Higher Maternal Plasma n-3 PUFA and Lower n-6 PUFA Concentrations in Pregnancy Are Associated with Lower Childhood Systolic Blood Pressure

卷:145

Vidakovic, Aleksandra Jelena ; Gishti, Olta ; Graaff, Jolien Steenweg-de ; Williams, Michelle A. ; Duijts, Liesbeth ; Felix, Janine F. ; Hofman, Albert ; Tiemeier, Henning ; Jaddoe, Vincent W. V. ; Gaillard, Romy

关键词: PUFAs;    pregnancy;    blood pressure;    childhood;    cohort;   

DOI  :  10.3945/jn.115.210823

学科分类：食品科学和技术

【 摘 要 】

Background: Suboptimal maternal diet during pregnancy might lead to fetal cardiovascular adaptations with persistent consequences in the offspring. Objective: We assessed the associations of maternal polyunsaturated fatty acid (PUFA) concentrations during pregnancy with childhood blood pressure. Methods: In a population-based prospective cohort study among 4455 mothers and their children, we measured maternal second-trimester n-3 (6)-3) and n-6 (0.)-6) PUFA concentrations in plasma glycerophospholipids and expressed n-3 and n-6 PUFAs as proportions of total PUFAs (wt%). Childhood blood pressure was measured at the median age of 6.0 y (95% range: 5.7-7.9 y). We used linear regression models to assess the associations of maternal PUFA wt% with childhood blood pressure at 6 y. Results: Higher total maternal ri,-3 PUFA wt% and, specifically, docosahexaenoic acid (DHA; 22:6n-3) wt% were associated with lower childhood systolic blood pressure [differences: -0.28(95% Cl: -0.54, -0.03) and -0.29 mm Hg (95% Cl: -0.54, -0.03) per SD increase of total n-3 PUFAs and DHA wt%, respectively], but not with childhood diastolic blood pressure. Total maternal n-6 PUFA wt% was positively associated with childhood systolic blood pressure [differences: 0.36mm Hg (95% Cl: 0.09, 0.62) per SD increase of total n-6 PUFA wt%], but not with childhood diastolic blood, pressure. A higher n-6:n-3 PUFA ratio was associated with higher childhood systolic blood pressure (P< 0.051. Pregnancy and childhood characteristics only partly explained the observed associations. Conclusions: Higher maternal plasma n-3 PUFA and lower n-6 PUFA concentrations during pregnancy are associated with a lower systolic blood pressure in childhood. Further studies are needed to replicate these findings, explore the underlying mechanisms, and examine the long-term cardiovascular consequences.