Imaging Atherosclerotic Plaque Inflammation by Fluorodeoxyglucose With Positron Emission Tomography

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

卷:55

Review

Rudd, James H. F.¹  Narula, Jagat^2,3  Strauss, H. William⁴  Virmani, Renu⁵  Machac, Josef⁶  Klimas, Mike⁸  Tahara, Nobuhiro⁹  Fuster, Valentin⁷  Warburton, Elizabeth A.¹  Fayad, Zahi A.⁷  Tawakol, Ahmed A.¹⁰ 

[1] Univ Cambridge, Div Cardiovasc Med, Cambridge CB2 2QQ, England

[2] Long Beach Mem Hosp Med Ctr, Irvine, CA USA

[3] Univ Calif Irvine, Irvine, CA USA

[4] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA

[5] CVPath Inst Inc, Gaithersburg, MD USA

[6] Mt Sinai Sch Med, Div Nucl Med, New York, NY USA

[7] Mt Sinai Sch Med, Translat & Mol Imaging Inst, New York, NY USA

[8] Merck Res Labs, West Point, PA USA

[9] Kurume Univ, Sch Med, Dept Med, Kurume, Fukuoka 830, Japan

[10] Massachusetts Gen Hosp, Dept Med, Boston, MA 02114 USA

关键词: atherosclerosis;    imaging;    positron emission tomography;   

DOI  :  10.1016/j.jacc.2009.12.061

来源: Elsevier

【 摘 要 】

Inflammation is a determinant of atherosclerotic plaque rupture, the event leading to most myocardial infarctions and strokes. Although conventional imaging techniques identify the site and severity of luminal stenosis, the inflammatory status of the plaque is not addressed. Positron emission tomography imaging of atherosclerosis using the metabolic marker fluorodeoxyglucose allows quantification of arterial inflammation across multiple vessels. This review sets out the background and current and potential future applications of this emerging biomarker of cardiovascular risk, along with its limitations. (J Am Coll Cardiol 2010;55:2527-35) (C) 2010 by the American College of Cardiology Foundation

【 授权许可】

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