Human Biodistribution and Radiation Dosimetry of 82Rb

Journal of Nuclear Medicine

Martin A. Lodge¹  Frank M. Bengel¹  Robert F. Hobbs¹  Jennifer Merrill¹  Srinivasan Senthamizhchelvan¹  George Sgouros¹  Paco E. Bravo¹  Caroline Esaias¹ 

[1] Division of Nuclear Medicine, Russell H. Morgan Department of Radiology, Johns Hopkins University, Baltimore, Maryland Division of Nuclear Medicine, Russell H. Morgan Department of Radiology, Johns Hopkins University, Baltimore, Maryland Division of Nuclear Medicine, Russell H. Morgan Department of Radiology, Johns Hopkins University, Baltimore, Maryland

关键词: myocardium;    imaging;    ⁸²Rb;    positron emission tomography;    dosimetry;   

DOI  :  10.2967/jnumed.110.077669

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

Prior estimates of radiation-absorbed doses from 82Rb, a frequently used PET perfusion tracer, yielded discrepant results. We reevaluated 82Rb dosimetry using human in vivo biokinetic measurements. Methods: Ten healthy volunteers underwent dynamic PET/CT (6 contiguous table positions, each with separate 82Rb infusion). Source organ volumes of interest were delineated on the CT images and transferred to the PET images to obtain time-integrated activity coefficients. Radiation doses were estimated using OLINDA/EXM 1.0. Results: The highest mean absorbed organ doses (μGy/MBq) were observed for the kidneys (5.81), heart wall (3.86), and lungs (2.96). Mean effective doses were 1.11 ± 0.22 and 1.26 ± 0.20 μSv/MBq using the tissue-weighting factors of the International Commission on Radiological Protection (ICRP), publications 60 and 103, respectively. Conclusion: Our current 82Rb dosimetry suggests reasonably low radiation exposure. On the basis of this study, a clinical 82Rb injection of 2 × 1,480 MBq (80 mCi) would result in a mean effective dose of 3.7 mSv using the weighting factors of the ICRP 103only slightly above the average annual natural background exposure in the United States (3.1 mSv).

【 授权许可】

Unknown