Basic Biology of Oxidative Stress and the Cardiovascular System Part 1 of a 3-Part Series

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

卷:70

Review

Sack, Michael N.¹  Fyhrquist, Frej Y.²  Saijonmaa, Outi J.²  Fuster, Valentin^3,4,5  Kovacic, Jason C.³ 

[1] NHLBI, Cardiovasc & Pulm Branch, NIH, Bldg 10, Bethesda, MD 20892 USA

[2] Minerva Fdn, Helsinki, Finland

[3] Icahn Sch Med Mt Sinai, Zena & Michael A Wiener Cardiovasc Inst, New York, NY 10029 USA

[4] Icahn Sch Med Mt Sinai, Marie Josee & Henry R Kravis Cardiovasc Hlth, New York, NY 10029 USA

[5] CNIC, Madrid, Spain

关键词: apoptosis;    mitochondria;    necrosis;    reactive oxygen species;    senescence;    sirtuin;    telomere;   

DOI  :  10.1016/j.jacc.2017.05.034

来源: Elsevier

【 摘 要 】

The generation of reactive oxygen species (ROS) is a fundamental aspect of normal human biology. However, when ROS generation exceeds endogenous antioxidant capacity, oxidative stress arises. If unchecked, ROS production and oxidative stress mediate tissue and cell damage that can spiral in a cycle of inflammation and more oxidative stress. This article is part 1 of a 3-part series covering the role of oxidative stress in cardiovascular disease. The broad theme of this first paper is the mechanisms and biology of oxidative stress. Specifically, the authors review the basic biology of oxidative stress, relevant aspects of mitochondrial function, and stress-related cell death pathways (apoptosis and necrosis) as they relate to the heart and cardiovascular system. They then explore telomere biology and cell senescence. As important regulators and sensors of oxidative stress, telomeres are segments of repetitive nucleotide sequence at each end of a chromosome that protect the chromosome ends from deterioration. (C) 2017 by the American College of Cardiology Foundation. Published by Elsevier. All rights reserved.

【 授权许可】

Free