Cp*Co(III)-catalyzed oxidative C-H alkenylation of benzamides with ethyl acrylate

TETRAHEDRON

卷:71

Article

Suzuki, Yudai¹  Sun, Bo¹  Yoshino, Tatsuhiko^1,2  Kanai, Motomu¹  Matsunaga, Shigeki^1,2,3 

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

[2] Japan Sci & Technol Agcy JST, ACT C, Bunkyo Ku, Tokyo 1130033, Japan

[3] Hokkaido Univ, Fac Pharmaceut Sci, Sapporo, Hokkaido 0600812, Japan

关键词: Cobalt;    Oxidation;    Alkenylation;    Catalysis;    C-H activation;   

DOI  :  10.1016/j.tet.2015.02.032

来源: Elsevier

【 摘 要 】

The utility of Cp-Co(III)-catalysts was expanded to oxidative C-C bond-forming reaction. In situ-generated Cp*Co(III)-catalyst, rather than a preformed cationic Cp*Co(III)-complex, was effective. Oxidative alkenylation of benzamides and acetanilide with ethyl acrylate proceeded with silver acetate as a stoichiometric oxidant, giving products in up to 93% yield. (C) 2015 Elsevier Ltd. All rights reserved.

【 授权许可】

Free