Synthesis of DBpin using Earth-abundant metal catalysis

TETRAHEDRON

卷:76

Article

Cummins, Andrew W. M.¹  Li, Shuyang¹  Willcox, Dominic R.¹  Muilu, Tommi²  Docherty, Jamie H.¹  Thomas, Stephen P.¹ 

[1] Univ Edinburgh, EaStCHEM Sch Chem, Joseph Black Bldg,David Brewster Rd, Edinburgh EH9 3FJ, Midlothian, Scotland

[2] Univ St Andrews North Haugh, Sch Chem, EaStCHEM, St Andrews KY16 9ST, Fife, Scotland

关键词: Catalysis;    Boron;    Iron;    Cobalt;    Deuterium;   

DOI  :  10.1016/j.tet.2020.131084

来源: Elsevier

【 摘 要 】

The synthesis of DBpin was achieved using ((BIP)-B-Et)CoCl2 or ((PNN)-P-tB-P-u)FeCl2 as pre-catalysts activated with (NaOBu)-Bu-t. ((BIP)-B-Et)CoCl2 was used as a pre-catalyst for the hydrogen isotope exchange of HBpin with D2, and ((PNN)-P-tBu) FeCl2 for deuterogenolysis of B(2)pin(2). The one-pot, tandem hydrogenolysis-hydroboration/deuterogenolysis-deuteroboration reaction of terminal alkenes could be catalysed by ((PNN)-P-tBu)FeCl2 to give alkyl boronic esters. (C) 2020 Elsevier Ltd. All rights reserved.

【 授权许可】

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