Rhodium(III)-catalyzed C-H functionalization of C-alkenyl azoles with sulfoxonium ylides for the synthesis of bridgehead N-fused [5,6]-bicyclic heterocycles

TETRAHEDRON

卷:74

Article; Proceedings Paper

Hoang, Gia L.¹  Ellman, Jonathan A.¹ 

[1] Yale Univ, Dept Chem, New Haven, CT 06520 USA

关键词: C-H functionalization;    Rhodium;    Sulfoxonium ylide;    Catalysis;    Nitrogen heterocycle;   

DOI  :  10.1016/j.tet.2018.03.062

来源: Elsevier

【 摘 要 】

The synthesis of bridgehead N-fused [5,6]-bicyclic heterocycles via rhodium(III)-catalyzed C-H functionalization of C-alkenyl azoles with sulfoxonium ylides is disclosed. Reactions proceeded in good to high yields for a range of aryl, heteroaryl and alkyl sulfoxonium ylides. In addition, 2-alkenyl imidazoles with different substitution patterns as well as C-alkenyl triazoles were effective inputs. The reaction could also be performed under straightforward bench top conditions. (C) 2018 Elsevier Ltd. All rights reserved.

【 授权许可】

Free