Studies toward the AB ring system of the tetrapetalone natural products

TETRAHEDRON

卷:71

Article

Carlsen, Peter N.¹  Jiang, Chao¹  Herrick, Ildiko R.¹  Frontier, Alison J.¹ 

[1] Univ Rochester, Dept Chem, Rochester, NY 14627 USA

关键词: Cross-coupling;    Cyclization;    Natural products;    Polycycles;   

DOI  :  10.1016/j.tet.2015.05.021

来源: Elsevier

【 摘 要 】

Synthetic efforts toward the rapid assembly of the AB ring system of the tetrapetalones is described. Key to this work was the use of [3+2] cycloaddition/oxidative extrusion methodology to furnish functionalized aryl enones. The Nazarov cydization of these substrates was examined, and optimized to generate the AB ring carbon skeleton. Then, Pd-catalyzed cross-coupling were conducted, and conditions were identified that enabled installatiion of the requisite C14-N bond. (C) 2015 Elsevier Ltd. All rights reserved.

【 授权许可】

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