Synthesis of a library of SCF2CO2Et reagents: An access to original (ethoxycarbonyl)difluoromethylthioesters

TETRAHEDRON

卷:98

Article

Petit-Cancelier, Fabien¹  Couve-Bonnaire, Samuel¹  Besset, Tatiana¹ 

[1] Normandie Univ, CNRS, UNIROUEN, INSA Rouen,COBRA UMR 6014, F-76000 Rouen, France

关键词: Difluoromethylthioester derivatives;    Fluorine chemistry;    Radical process;    Mild reaction conditions;    Aldehydes;   

DOI  :  10.1016/j.tet.2021.132446

来源: Elsevier

【 摘 要 】

A library of original and shelf-stable reagents, source of the (ethoxycarbonyl)difluoromethylthio group, is reported. These reagents are applied to the functionalization of a large panel of aldehydes via a transition metal-free protocol under mild reaction conditions. This approach offers an efficient access to valuable difluoromethylthioester derivatives. (c) 2021 Elsevier Ltd. All rights reserved.

【 授权许可】

Free