Novel hydrazones _ antioxidant potential and stabilization via polysaccharide particles

INERA Workshop 2016: Membrane and Liquid Crystal Nanostructures

Hristova-Avakumova, N.^1 ; Nikolova-Mladenova, B.^2 ; Yoncheva, K.^3 ; Hadjimitova, V.^1

Department of Medical Physics and Biophysics, Faculty of Medicine, Medical University of Sofia, Bulgaria^1

Department of Chemistry, Faculty of Pharmacy, Medical University of Sofia, Bulgaria^2

Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, Medical University of Sofia, Bulgaria^3

关键词: Anti-oxidant activities;    Antioxidant potential;    Antioxidant properties;    Chitosan alginates;    Radical process;    Radical scavenging;    Radical scavenging activity;    Salicylaldehyde;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/780/1/012004/pdf
DOI  :  10.1088/1742-6596/780/1/012004

来源: IOP

【 摘 要 】

In this study, we aimed to: i) determine the impact of three new isonicotinoyl hydrazones derivatives in in vitro systems used to investigate free radical processes - radical scavenging approach (ABTS and DPPH) and iron induced peroxidation in lipid containing model systems and ii) evaluate the potential of polysaccharide-based particles to act as protective carriers preserving the antioxidant activity (AOA) of the tested compounds. The tested compounds revealed excellent antioxidant effectiveness in the ABTS system. In the DPPH radical scavenging assay the compounds exhibited very weak or absence of AOA. The data from the iron induced peroxidation methods disclosed better antioxidant properties of the derivatives in the system containing egg yolk homogenate which is more plausible compared to the lecithin containing one. The incorporation of a bromine atom on 5thposition in salicylaldehyde moiety is associated with diminishment of the radical scavenging activity in the systems containing stable free radicals but its AOA reduction after encapsulation during the storage was only 9.17%. The obtained data indicate that compounds have proven themselves as promising candidates for further evaluation as antioxidant agents. Their encapsulation in chitosan-alginate particles could be a useful approach for improving the stability of their antioxidant properties.