An approach for the synthesis of nakamuric acid

TETRAHEDRON

卷:71

Article

Wang, Xiaolei¹  Chen, Chuo¹ 

[1] Univ Texas SW Med Ctr Dallas, Dept Biochem, Dallas, TX 75390 USA

关键词: Single-electron transfer;    Radical;    Cyclization;    Imidazole;    Pyrrole;   

DOI  :  10.1016/j.tet.2014.10.027

来源: Elsevier

【 摘 要 】

The biosynthesis of dimeric pyrrole imidazole alkaloids is likely mediated by enzyme-catalyzed reversible single-electron transfer (SET) cycloaddition. We now show that Ir(ppy)(3) can promote SET-mediated formal [2+2] and [4+2] cycloaddition reactions of pyrrole imidazole alkaloids-related substrates under photolytic conditions. This biomimetic approach is useful for the construction of the core skeleton of nakamuric acid and sceptrin. (C) 2014 Elsevier Ltd. All rights reserved.

【 授权许可】

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