On the mechanism of enzymatic lignin breakdown

FEBS Letters

Schoemaker, H.E.¹  Bowen, R.M.²  Harvey, P.J.²  Palmer, J.M.² 

[1] Central Laboratory DSM, PO Box 18, NL-6160 MD Geleen, The Netherlands;Department of Pure and Applied Biology, Imperial College, Prince Consort Road, London SW7 2BB, England

关键词: Lignin degradation;    Phanerochaete chrysosporium;    Single-electron transfer;    Radical cation;    Peroxidase compound I;    Active oxygen;    CAN;    ceric ammonium nitrate;    tris(phenanthroline)iron(III);    tris(phenanthroline)iron(III);    PhIO;    iodosylbenzene;    TPP(Fe)Cl;    tetraphenylporphyrinatoiron(III)chloride;   

DOI  :  10.1016/0014-5793(85)80942-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The recent discovery of an extracellular enzyme from Phanerochaete chrysosporium capable of degrading lignin model compounds has countered the view that reactive diffusible oxygen species are responsible for lignin biodegradation. In this paper we propose a mechanism which accounts for both the results obtained in enzymatic lignin degradation studies and in studies involving active oxygen species. The quintessence of the mechanism is initial one-electron oxidation of the lignin model compounds or of a specific lignin subunit followed by subsequent breakdown reactions via radical cation intermediates. The implication of this type of mechanism on the oxidative biodegradation of the natural lignin polymer is discussed.

【 授权许可】

Unknown