Stereochemical evaluation of bis(phosphine) copper catalysts for the asymmetric alkylation of 3-bromooxindoles with α-arylated malonate esters

TETRAHEDRON

卷:71

Article

Lee, Chung Whan¹  Han, Seo-Jung¹  Virgil, Scott C.¹  Stoltz, Brian M.¹ 

[1] CALTECH, Warren & Katharine Schlinger Lab Chem & Chem Engn, Div Chem & Chem Engn, Pasadena, CA 91125 USA

关键词: 3,3-Disubstituted oxindole;    Chiral bis(phosphine) ligands;    Copper catalysis;    Asymmetric catalysis;   

DOI  :  10.1016/j.tet.2014.10.065

来源: Elsevier

【 摘 要 】

An improved method for the asymmetric alkylation of 3-bromooxindoles with alpha-arylated malonate esters is described. The asymmetric alkylation demonstrated was achieved up to 70% ee utilizing a copper(II) bis(phosphine) complex. (C) 2014 Elsevier Ltd. All rights reserved.

【 授权许可】

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