CuII-catalyzed regioselective borylation of alkynes and alkenes

TETRAHEDRON LETTERS

卷:57

Article

Liu, Shiwen¹  Zeng, Xiaojun¹  Xu, Bo¹ 

[1] Donghua Univ, Coll Chem Chem Engn & Biotechnol, 2999 North Renmin Lu, Shanghai 201620, Peoples R China

关键词: Ligand effects;    Copper catalysis;    Borylation;    Alkyne;    Alkene;   

DOI  :  10.1016/j.tetlet.2016.06.077

来源: Elsevier

【 摘 要 】

We developed a regioselective borylation of alkynes and alkenes protocol based on air-stable Cu-II/multidentate ligand system. Our catalytic system gives exclusive beta-borylation products for most substrates in excellent chemical yields. We propose that multi-dentate electron poor nitrogen ligands can effectively discourage the formation of alpha-addition product through the steric hindrance and at same time maintain good reactivity. (C) 2016 Elsevier Ltd. All rights reserved.

【 授权许可】

Free