Versatile and base-free copper-catalyzed α-arylations of aromatic ketones using diaryliodonium salts

TETRAHEDRON LETTERS

卷:75

Article

Bouquin, Maxime¹  Jaroschik, Florian¹  Taillefer, Marc¹ 

[1] Univ Montpellier, ENSCM, CNRS, ICGM, F-34090 Montpellier, France

关键词: Copper catalysis;    alpha-Arylation;    Diaryliodonium;    Silyl enol ether;   

DOI  :  10.1016/j.tetlet.2021.153208

来源: Elsevier

【 摘 要 】

A ligand and base-free copper catalyzed synthetic method for the efficient alpha-arylation of aromatic ketones is described. In order to avoid strong bases, ketone-derived silyl enol ethers were employed. Their reaction with diaryliodonium salts as aryl source provided the intermolecular C-C coupling displaying good functional group tolerance and requiring low catalyst loading. (C) 2021 Elsevier Ltd. All rights reserved.

【 授权许可】

Free