Efficient synthesis of novel chalcogen-containing derivatives of DNA nucleobases

TETRAHEDRON

卷:71

Article

Hua, Guoxiong¹  Du, Junyi¹  Cordes, David B.¹  Slawin, Alexandra M. Z.¹  Woollins, J. Derek¹ 

[1] Univ St Andrews, EaStCHEM Sch Chem, St Andrews KY16 9ST, Fife, Scotland

关键词: DNA nucleobases;    9-(2-Bromoethyl)adenine;    Adenine derivatives;    Chalcogens;    Woollins' reagent;   

DOI  :  10.1016/j.tet.2015.02.005

来源: Elsevier

【 摘 要 】

The formation of a library of chalcogen-containing DNA nucleobase derivatives is presented. Reacting easily accessible 9-(2-bromoethyl)adenine with chalcogen-containing nucleophilic reagents led to a series of novel heteroatom derivatives incorporating S, Se and Te atoms in satisfactory yields. Two representative X-ray structures are reported. (C) 2015 Elsevier Ltd. All rights reserved.

【 授权许可】

Free