Straightforward synthesis and antioxidant studies of chalcogenoaziridines

TETRAHEDRON LETTERS

卷:57

Article

Borges, Rodrigo¹  Andrade, Floyd C. D.²  Schwab, Ricardo S.²  Sousa, Fernanda S. S.³  de Souza, Maurice Neto³  Savegnago, Lucielli³  Schneider, Paulo H.¹ 

[1] Univ Fed Rio Grande do Sul, Inst Quim, POB 15003, BR-91501970 Porto Alegre, RS, Brazil

[2] Univ Fed Sao Carlos, UFSCar, Dept Quim, BR-13565905 Sao Carlos, SP, Brazil

[3] Univ Fed Pelotas, Grp Pesquisa Neurobiotecnol, Pelotas, RS, Brazil

关键词: Chalcogenoaziridines;    Selenium;    Aziridines;    Antioxidant;    Chalcogens;   

DOI  :  10.1016/j.tetlet.2016.06.101

来源: Elsevier

【 摘 要 】

Herein we reported the synthesis of chalcogenoaziridines through the introduction of the organoselenium moiety in the aziridine framework through the nucleophilic substitution of the OTs leaving group. In addition, the antioxidant activity, as reflected by free radical scavenging, was also evaluated. The new seleno aziridine 6a showed more effective antioxidant compared to other compounds. These findings also suggest that seleno aziridine 6a is a promising antioxidant and that its activity is not influenced by the presence of the substituents attached into the aromatic ring. (C) 2016 Elsevier Ltd. All rights reserved.

【 授权许可】

Free