Facile syntheses of functionalized toll-like receptor 7 agonists

TETRAHEDRON LETTERS

卷:56

Article

Akinbobuyi, Babatope¹  Byrd, Matthew R.¹  Chang, Charles A.²  Nguyen, Mysa¹  Seifert, Zacharie J.¹  Flamar, Anne-Laure³  Zurawski, Gerard^2,3  Upchurch, Katherine C.²  Oh, SangKon^2,3  Dempsey, Stephen H.⁴  Enke, Thomas J.⁴  Le, John⁴  Winstead, Hunter J.⁴  Boquin, Jose R.⁴  Kane, Robert R.^1,2,3 

[1] Baylor Univ, Dept Chem & Biochem, Waco, TX 76798 USA

[2] Baylor Univ, Inst Biomed Studies, Waco, TX 76798 USA

[3] Baylor Res Inst, Baylor Inst Immunol Res, Dallas, TX 75204 USA

[4] Augustana Coll, Dept Chem, Rock Isl, IL 61201 USA

关键词: Toll-like receptor;    Adenine derivatives;    Vaccines;    Immune activation;   

DOI  :  10.1016/j.tetlet.2014.11.126

来源: Elsevier

【 摘 要 】

Protein conjugates of toll-like receptor 7 agonists have been shown to elicit powerful immune responses. In order to facilitate our studies in this area our group has developed efficient syntheses for a number of functionalized derivatives that retain immune stimulatory activity. (C) 2014 Elsevier Ltd. All rights reserved.

【 授权许可】

Free