Microfluidic diatomite analytical devices for illicit drug sensing with ppb-Level sensitivity

SENSORS AND ACTUATORS B-CHEMICAL

卷:259

Article

Kong, Xianming^1,2  Chong, Xinyuan²  Squire, Kenny²  Wang, Alan X.² 

[1] Liaoning Shihua Univ, Coll Chem Chem Engn & Environm Engn, Fushun 113001, Liaoning, Peoples R China

[2] Oregon State Univ, Sch Elect Engn & Comp Sci, Corvallis, OR 97331 USA

关键词: Drug detection;    Microfluidic device;    Photonic crystals;    Point-of-care;    Lab-on-a-chip;   

DOI  :  10.1016/j.snb.2017.12.038

来源: Elsevier

【 摘 要 】

The escalating research interests in porous media microfluidics, such as microfluidic paper-based analytical devices, have fostered a new spectrum of biomedical devices for point-of-care (POC) diagnosis and biosensing. In this paper, we report microfluidic diatomite analytical devices (mu DADs), which consist of highly porous photonic crystal biosilica channels, as an innovative lab-on-a-chip platform to detect illicit drugs. The mu DADs in this work are fabricated by spin-coating and tape-stripping diatomaceous earth on regular glass slides with cross section of 400 x 30 mu m(2). As the most unique feature, our mu DADs can simultaneously perform on-chip chromatography to separate small molecules from complex biofluidic samples and acquire the surface-enhanced Raman scattering spectra of the target chemicals with high specificity. Owing to the ultra-small dimension of the diatomite microfluidic channels and the photonic crystal effect from the fossilized diatom frustules, we demonstrate unprecedented sensitivity down to part-per-billion (ppb) level when detecting pyrene (1ppb) from mixed sample with Raman dye and cocaine (10 ppb) from human plasma. This pioneering work proves the exclusive advantage of mu DADs as emerging microfluidic devices for chemical and biomedical sensing, especially for POC drug screening. (C) 2017 Elsevier B.V. All rights reserved.

【 授权许可】

Free