Highly sensitive amperometric sensor for morphine detection based on electrochemically exfoliated graphene oxide. Application in screening tests of urine samples

SENSORS AND ACTUATORS B-CHEMICAL

卷:281

Article

Maccaferri, Giulio^1,2  Terzi, Fabio¹  Xia, Zhenyuan³  Vulcano, Fabio¹  Liscio, Andrea⁴  Palermo, Vincenzo^2,3  Zanardi, Chiara^1,2 

[1] Univ Modena & Reggio Emilia, Dept Chem & Geol Sci, Via G Campi 103, I-41125 Modena, Italy

[2] CNR, ISOF, Via Gobetti 101, I-40129 Bologna, Italy

[3] Chelmers Univ Technol, Dept Ind & Mat Sci, SE-41296 Gothenburg, Sweden

[4] CNR, Sez Roma, IMM, Via Fosso del Cavaliere 100, I-00133 Rome, Italy

关键词: Morphine;    Graphene;    Electrocatalysis;    Drug detection;    Screening tests;    Urine samples;   

DOI  :  10.1016/j.snb.2018.10.163

来源: Elsevier

【 摘 要 】

Graphene oxide modified screen-printed electrodes have been tested as amperometric sensors for morphine determination. The results demonstrate that the arising of electrocatalytic processes ascribable to the graphene coating, combined with the use of a suitable cleaning procedure, allow the sensor to achieve higher sensitivity (2.61 nA ppb(-1)) and lower limit of detection (2.5 ppb) with respect to those reported in the literature for similar devices. Due to very low detection limit found, the device is suitable to detect the presence of morphine in urine samples after a very simple and rapid pre-treatment of the matrix, allowing the removal of interfering species affecting the voltammetric responses. Tests performed in synthetic urine samples demonstrate that the presence of the electrocatalytic coating is mandatory in resolving the peak due to morphine oxidation in respect to uric acid. The sensor proposed is, thus, suitable to detect this drug even at concentration values below the cut-off levels defined by European and American regulations. These results allow us to propose the sensor for screening tests in portable devices, to be applied in systematic controls of drug abuses, e.g. in drivers and in men at work.

【 授权许可】

Free