Mitigating positional dependence in coplanar electrode Coulter-type microfluidic devices

SENSORS AND ACTUATORS B-CHEMICAL

卷:247

Article

Errico, Vitro¹  De Ninno, Adele¹  Bertani, Francesca Romana²  Businaro, Luca²  Bisegna, Paolo¹  Caselli, Federica¹ 

[1] Univ Roma Tor Vergata, Dept Civil Engn & Comp Sci, I-00133 Rome, Italy

[2] Italian Natl Res Council, Inst Photon & Nanotechnol, I-00156 Rome, Italy

关键词: Impedance cytometry;    Coplanar electrodes;    Microfluidics;    Single-cell analysis;   

DOI  :  10.1016/j.snb.2017.03.035

来源: Elsevier

【 摘 要 】

Microfluidic impedance-based devices with coplanar electrode layout represent an attractive tool for low-cost, label-free, single-cell analysis. However, their usefulness has long been limited by the positional dependence of the measured signals, i.e., identical particles traveling along different paths provide different traces. In this paper we show that it is possible to significantly reduce this unwanted effect via straightforward signal processing, by exploiting the richness of the information contained in the recorded traces. (C) 2017 The Author(s). Published by Elsevier B.V.

【 授权许可】

Free