A new fluorescent chemosensor for Zn2+ with facile synthesis: Turn-on response in water at neutral pH and its application for live cell imaging

SENSORS AND ACTUATORS B-CHEMICAL

卷:184

Article

Li, Kai¹  Tong, Aijun¹ 

[1] Tsinghua Univ, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Beijing Key Lab Analyt Methods & Instrumentat, Dept Chem, Beijing 100084, Peoples R China

关键词: Zinc;    Fluorescence turn-on;    Chemosensor;    Cell imaging;   

DOI  :  10.1016/j.snb.2013.04.083

来源: Elsevier

【 摘 要 】

A series of salicylaldehyde-2-pyridinehydrazone derivatives were found to exhibit interesting turnon fluorescence response toward Zn2+ in water at neutral pH, which could be prepared readily from commercially available materials through a one-step reaction in ethanol at room temperature. Among these compounds, 1 showed a 22-fold fluorescence enhancement in 99% water/DMSO (v/v) at pH 7.0 with a linear range of 0.10-1.00 mu mol/L and detection limit of 30 nmol/L Zn2+. Especially, 1 was not affected by Cd2+ which usually induced a comparable fluorescence response to that of Zn2+ in other reported works. Moreover, live cell imaging showed that 1 could be useful for monitoring Zn2+ within biological samples. (C) 2013 Elsevier B.V. All rights reserved.

【 授权许可】

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