One-step synthesis of cyclodextrin-capped gold nanoparticles for ultra-sensitive and highly-integrated plasmonic biosensors

SENSORS AND ACTUATORS B-CHEMICAL

卷:286

Article

Zhang, Nancy Meng Ying^1,2  Qi, Miao¹  Wang, Zhixun¹  Wang, Zhe¹  Chen, Mengxiao¹  Li, Kaiwei¹  Shum, Ping^1,2  Wei, Lei^1,2 

[1] Nanyang Technol Univ, Sch Elect & Elect Engn, 50 Nanyang Ave, Singapore 639798, Singapore

[2] CINTRA CNRS NTU THALES, UMI3288, Res Techno Plaza,50 Nanyang Dr, Singapore 637553, Singapore

关键词: Localized surface plasmon resonance;    Biosensing;    Gold nanoparticles synthesis;    Supramolecular chemistry;    Fiber optics;    Cholesterol;   

DOI  :  10.1016/j.snb.2019.01.166

来源: Elsevier

【 摘 要 】

Plasmonics in conjunction with supramolecular chemistry brings new opportunities for biosensing. Modified with macrocyclic supramolecules, noble metal nanoparticles possess improved biocompatibility and highly efficient biomolecule immobilization and recognition via host-guest interaction. In this work, we synthesize high-quality and monodisperse beta-cyclodextrin-capped gold nanoparticles (beta-CD-capped AuNPs) in one-step facile and eco-friendly process, where beta-CD functions as both reducing and capping agent. Integrated with a microfiber, the beta-CD-capped AuNPs deliver promising localized surface plasmon resonance properties and ultralow detection limit of cholesterol molecules of 5 aM. The selective recognition of our proposed biosensor to cholesterol is further verified by interference study and analysis of real human serum samples. This study shows the bright prospects of supramolecular chemistry assisted plasmonics in achieving highly integrated and highly sensitive biosensing with extremely low consumption of clinical samples and small footprint.

【 授权许可】

Free