Nimodipine reduction of naltrexone-precipitated locus coeruleus activation and abstinence behavior in morphine-dependent rats

PHYSIOLOGY & BEHAVIOR

卷:59

Article

Krystal, JH ; Compere, S ; Nestler, EJ ; Rasmussen, K

关键词: opiate;    morphine;    withdrawal;    naltrexone;    nimodipine;    locus coeruleus;    electrophysiology;   

DOI  :  10.1016/0031-9384(95)02206-6

来源: Elsevier

【 摘 要 】

Single-unit recordings in anesthetized animals revealed that the L-type calcium channel antagonist, nimodipine (10 mg/kg), attenuated the activation of locus coeruleus neurons produced by naltrexone in opiate-dependent rats. Nimodipine also dose-dependently (1 mg/kg, 10 mg/kg, IP) inhibited the display of naloxone-precipitated withdrawal behaviors with a time course similar to that of nimodipine effects on the locus coeruleus. These data suggest that nimodipine may suppress opiate withdrawal via noradrenergic mechanisms.

【 授权许可】

Free