Effects of high-fat diet exposure on learning & memory

PHYSIOLOGY & BEHAVIOR

卷:152

Article; Proceedings Paper

Cordner, Zachary A.¹  Tamashiro, Kellie L. K.¹ 

[1] Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Cellular & Mol Med Grad Program, Baltimore, MD 21205 USA

关键词: High-fat diet;    Cognition;    Learning;    Memory;    Animal models;    Behavior;   

DOI  :  10.1016/j.physbeh.2015.06.008

来源: Elsevier

【 摘 要 】

The associations between consumption of a high-fat or 'Western' diet and metabolic disorders such as obesity, diabetes, and cardiovascular disease have long been recognized and a great deal of evidence now suggests that diets high in fat can also have a profound impact on the brain, behavior, and cognition. Here, we will review the techniques most often used to assess learning and memory in rodent models and discuss findings from studies assessing the cognitive effects of high-fat diet consumption. The review will then consider potential underlying mechanisms in the brain and conclude by reviewing emerging literature suggesting that maternal consumption of a high-fat diet may have effects on the learning and memory of offspring. (C) 2015 Elsevier Inc All rights reserved.

【 授权许可】

Free