Role of caloric homeostasis and reward in alcohol intake in Syrian golden hamsters

PHYSIOLOGY & BEHAVIOR

卷:101

Article

Gulick, Danielle^1,2  Green, Alan I.^1,2 

[1] Dartmouth Med Sch, Dept Psychiat, Lebanon, NH 03756 USA

[2] Dartmouth Med Sch, Ctr Neurosci, Lebanon, NH 03756 USA

关键词: Alcoholism;    Caloric balancing;    Ethanol;    Reward;   

DOI  :  10.1016/j.physbeh.2010.07.019

来源: Elsevier

【 摘 要 】

The Syrian golden hamster drinks alcohol readily but only achieves moderate blood alcohol levels and does not go through withdrawal from alcohol Because the hamster is a model of caloric homeostasis both caloric content and reward value may contribute to the hamsters alcohol consumption The current study examines alcohol consumption in the hamster when a caloric or non-caloric sweet solution is concurrently available and caloric intake in the hamster before during and after exposure to either alcohol sucrose or saccharin In Experiments 1 and 2 hamsters were given access to alcohol (15% v/v) and water once alcohol consumption steadied a bottle containing an ascending concentration of sucrose (99-614 mM) or saccharin (2-10 mM) or water was added In Experiment 3 hamsters were given access to alcohol (15% v/v) sucrose (614 mM) saccharin (4 mM) or a second water bottle for 14 days After the second bottle was removed measurements continued for 14 days Sucrose exposure suppressed alcohol consumption at concentrations lower in calories than the alcohol solution Saccharin exposure failed to suppress alcohol consumption Exposure to sucrose and alcohol but not saccharin decreased food intake Decreased alcohol consumption in response to a caloric sweetener and decreased food intake during alcohol exposure support that alcohol consumption by the hamster is mediated by caloric content However suppression of alcohol Intake by a sucrose solution of lower caloric content and the equivalent intake of individual alcohol sucrose and saccharin solutions support a rote for reward value in alcohol consumption (C) 2010 Elsevier Inc. All rights reserved

【 授权许可】

Free